Co-solubilization of Lamotrigine by Complexation and Micellization in Binary Solvent Mixtures

被引：12

作者：

Azarbayjani, Anahita Fathi ^{[1
,2
]}

Sajed-Amin, Sanaz ^{[3
]}

Panahi-Azar, Vahid ^{[4
]}

Asadpour-Zeynali, Karim ^{[5
]}

Jouyban, Abolghasem ^{[6
,7
,8
]}

机构：

[1] Urmia Univ Med Sci, Sch Pharm, Dept Pharmaceut, Orumiyeh, Iran

[2] Urmia Univ Med Sci, Solid Tumor Res Ctr, Orumiyeh, Iran

[3] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[4] Tabriz Univ Med Sci, Liver & Gastrointestinal Dis Res Ctr, Tabriz, Iran

[5] Univ Tabriz, Dept Analyt Chem, Fac Chem, Tabriz, Iran

[6] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz 51664, Iran

[7] Tabriz Univ Med Sci, Fac Pharm, Tabriz 51664, Iran

[8] Tabriz Univ Med Sci, Kimia Idea Pardaz Azarbayjan KIPA Sci Based Co, Tabriz 51664, Iran

来源：

CHEMICAL ENGINEERING RESEARCH & DESIGN | 2016年 / 105卷

关键词：

Solubility; Cosolvency; Complexing agents; Micelization; Jouyban-Acree model; PLUS WATER MIXTURES; SODIUM DODECYL-SULFATE; POORLY SOLUBLE DRUGS; BETA-CYCLODEXTRIN; COSOLVENT; SURFACTANTS; BEHAVIOR; RELEASE; DISSOLUTION; PREDICTION;

D O I：

10.1016/j.cherd.2015.10.037

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

The present work was carried out with the purpose of evaluating the effect of p-cyclodextrin ((3-CD), sodium lauryl sulfate (SLS) and polyethylene glycol 200 (PEG 200) on the solubilization of lamotrigine by means of phase-solublility studies and solubility prediction using Jouyban-Acree model. The experimental solubility values of various mixtures were fitted to the equation and fitting accuracy of solubility data to this model was evaluated. A quantitative relationship between the solubilizing agents was assessed and the predictive accuracy of the Jouyban-Acree model and its applicability assuring reliable prediction of the model in binary systems was studied. The significance of the simultaneous presence of SLS and (3-CD on lamotrigine solubility was studied in binary solvent mixture. (C) 2015 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.

引用

页码：64 / 70

页数：7

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