Octogenarian newly diagnosed multiple myeloma patients without geriatric impairments: the role of age >80 in the IMWG frailty score

被引:10
作者
D'Agostino, Mattia [1 ]
Larocca, Alessandra [1 ]
Offidani, Massimo [2 ]
Liberati, Anna Marina [3 ]
Gaidano, Gianluca [4 ]
Petrucci, Maria Teresa [5 ]
Derudas, Daniele [6 ]
Capra, Andrea [1 ]
Zambello, Renato [7 ]
Cascavilla, Nicola [8 ]
de Fabritiis, Paolo [9 ]
Innao, Vanessa [10 ]
Bonello, Francesca [1 ]
Patriarca, Francesca [11 ,12 ]
Benevolo, Giulia [13 ]
Giuliani, Nicola [14 ,15 ]
Aitoro, Gabriele [16 ,17 ,18 ]
Guglielmelli, Tommasina [19 ]
Di Raimondo, Francesco [20 ]
Corradini, Paolo [21 ]
Musto, Pellegrino [22 ,23 ]
Hajek, Roman [24 ,25 ]
Sonneveld, Pieter [26 ]
Boccadoro, Mario [1 ]
Bringhen, Sara [1 ]
机构
[1] Univ Torino, Div Hematol, Myeloma Unit, Azienda Osped Univ Citta Salute & Sci Torino, Turin, Italy
[2] AOU Osped Riuniti Ancona, Clin Ematol, Ancona, Italy
[3] Univ Perugia, Azienda Osped Santa Maria, Terni, Italy
[4] Univ Piemonte Orientale, Div Hematol, Dept Translat Med, I-28100 Novara, Italy
[5] Sapienza Univ Rome, Dept Translat & Precis Med, Azienda Osped Policlin Umberto I, Hematol, Rome, Italy
[6] Osped Oncol Riferimento Reg A Businco, SC Ematol & CTMO, ARNAS G Brozu, Cagliari, Italy
[7] Padova Univ, Sch Med Hematol & Clin Immunol, Padua, Italy
[8] IRCCS Casa Sollievo Sofferenza, Div Hematol, San Giovanni Rotondo, Italy
[9] Tor Vergata Univ, St Eugenio Hosp ASL Roma 2, Hematol, Rome, Italy
[10] Univ Messina, Dept Human Pathol Adulthood & Childhood, Div Hematol, I-98122 Messina, Italy
[11] Univ Udine, Clin Ematol, Azienda Sanit Univ Friuli Cent ASUFC, Dipartimento Area Med DAME, Udine, Italy
[12] Univ Udine, Unita Terapie Cellulari, Azienda Sanit Univ Friuli Cent ASUFC, Dipartimento Area Med DAME, Udine, Italy
[13] AO Citta Salute & Sci, SC Hematol, Turin, Italy
[14] Univ Parma, Azienda Osped Univ, Hematol, Parma, Italy
[15] Univ Parma, Dept Med & Surg, Parma, Italy
[16] Azienda Sanit Locale Torino 4, Dept Med, Cirie, Italy
[17] Azienda Sanit Locale Torino 4, Dept Med, Chivasso, Italy
[18] Azienda Sanit Locale Torino 4, Dept Med, Ivrea, Italy
[19] Osped San Luigi Gonzaga, Ematol, Orbassano, Italy
[20] Univ Catania, AOU Policlin, Div Hematol, Catania, Italy
[21] Univ Milan, Div Ematol, Fdn IRCCS Ist Nazl Tumori Milano, Milan, Italy
[22] Aldo Moro Univ, Dept Emergency & Organ Transplantat, Sch Med, Bari, Italy
[23] AOUC Policlin, Unit Hematol & Stem Cell Transplantat, Bari, Italy
[24] Univ Hosp Ostrava, Dept Haematooncol, Ostrava, Czech Republic
[25] Univ Ostrava, Fac Med, Ostrava, Czech Republic
[26] Erasmus MC Canc Inst, Dept Hematol, Rotterdam, Netherlands
关键词
BORTEZOMIB;
D O I
10.1038/s41408-021-00464-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页数:5
相关论文
共 11 条
[1]   Lenalidomide-based induction and maintenance in elderly newly diagnosed multiple myeloma patients: updated results of the EMN01 randomized trial [J].
Bringhen, Sara ;
D'Agostino, Mattia ;
Paris, Laura ;
Ballanti, Stelvio ;
Pescosta, Norbert ;
Spada, Stefano ;
Pezzatti, Sara ;
Grasso, Mariella ;
Rota-Scalabrini, Delia ;
De Rosa, Luca ;
Pavone, Vincenzo ;
Gazzera, Giulia ;
Aquino, Sara ;
Poggiu, Marco ;
Santoro, Armando ;
Gentile, Massimo ;
Baldini, Luca ;
Petrucci, Maria Teresa ;
Tosi, Patrizia ;
Marasca, Roberto ;
Cellini, Claudia ;
Palumbo, Antonio ;
Falco, Patrizia ;
Hajek, Roman ;
Boccadoro, Mario ;
Larocca, Alessandra .
HAEMATOLOGICA, 2020, 105 (07) :1937-1947
[2]   Early mortality in myeloma patients treated with first-generation novel agents thalidomide, lenalidomide, bortezomib at diagnosis: A pooled analysis [J].
Bringhen, Sara ;
Offidani, Massimo ;
Palmieri, Salvatore ;
Pisani, Francesco ;
Rizzi, Rita ;
Spada, Stefano ;
Evangelista, Andrea ;
Di Renzo, Nicola ;
Musto, Pellegrino ;
Marcatti, Magda ;
Vallone, Roberto ;
Storti, Sergio ;
Bernardini, Annalisa ;
Centurioni, Riccardo ;
Aitini, Enrico ;
Palmas, Angelo ;
Annibali, Ombretta ;
Angelucci, Emanuele ;
Ferrando, Paola ;
Baraldi, Anna ;
Rocco, Stefano ;
Andriani, Alessandro ;
Siniscalchi, Agostina ;
De Stefano, Valerio ;
Meneghini, Vittorio ;
Palumbo, Antonio ;
Grammatico, Sara ;
Boccadoro, Mario ;
Larocca, Alessandra .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2018, 130 :27-35
[3]   Carfilzomib, cyclophosphamide, and dexamethasone in patients with newly diagnosed multiple myeloma: a multicenter, phase 2 study [J].
Bringhen, Sara ;
Petrucci, Maria Teresa ;
Larocca, Alessandra ;
Conticello, Concetta ;
Rossi, Davide ;
Magarotto, Valeria ;
Musto, Pellegrino ;
Boccadifuoco, Luana ;
Offidani, Massimo ;
Omede, Paola ;
Gentilini, Fabiana ;
Ciccone, Giovannino ;
Benevolo, Giulia ;
Genuardi, Mariella ;
Montefusco, Vittorio ;
Oliva, Stefania ;
Caravita, Tommaso ;
Tacchetti, Paola ;
Boccadoro, Mario ;
Sonneveld, Pieter ;
Palumbo, Antonio .
BLOOD, 2014, 124 (01) :63-69
[4]   A phase 2 study of three low-dose intensity subcutaneous bortezomib regimens in elderly frail patients with untreated multiple myeloma [J].
Larocca, A. ;
Bringhen, S. ;
Petrucci, M. T. ;
Oliva, S. ;
Falcone, A. P. ;
Caravita, T. ;
Villani, O. ;
Benevolo, G. ;
Liberati, A. M. ;
Morabito, F. ;
Montefusco, V. ;
Passera, R. ;
De Rosa, L. ;
Omede, P. ;
Vincelli, I. D. ;
Spada, S. ;
Carella, A. M. ;
Ponticelli, E. ;
Derudas, D. ;
Genuardi, M. ;
Guglielmelli, T. ;
Nozzoli, C. ;
Aghemo, E. ;
De Paoli, L. ;
Conticello, C. ;
Musolino, C. ;
Offidani, M. ;
Boccadoro, M. ;
Sonneveld, P. ;
Palumbo, A. .
LEUKEMIA, 2016, 30 (06) :1320-1326
[5]   Dose/schedule-adjusted Rd-R vs continuous Rd for elderly, intermediate-fit patients with newly diagnosed multiple myeloma [J].
Larocca, Alessandra ;
Bonello, Francesca ;
Gaidano, Gianluca ;
D'Agostino, Mattia ;
Offidani, Massimo ;
Cascavilla, Nicola ;
Capra, Andrea ;
Benevolo, Giulia ;
Tosi, Patrizia ;
Galli, Monica ;
Marasca, Roberto ;
Giuliani, Nicola ;
Bernardini, Annalisa ;
Antonioli, Elisabetta ;
Rota-Scalabrini, Delia ;
Cellini, Claudia ;
Pompa, Alessandra ;
Monaco, Federico ;
Patriarca, Francesca ;
di Toritto, Tommaso Caravita ;
Corradini, Paolo ;
Tacchetti, Paola ;
Boccadoro, Mario ;
Bringhen, Sara .
BLOOD, 2021, 137 (22) :3027-3036
[6]   Patient-centered practice in elderly myeloma patients: an overview and consensus from the European Myeloma Network (EMN) [J].
Larocca, Alessandra ;
Dold, Sandra Maria ;
Zweegman, Sonja ;
Terpos, Evangelos ;
Waesch, Ralph ;
D'Agostino, Mattia ;
Scheubeck, Sophia ;
Goldschmidt, Hartmut ;
Gay, Francesca ;
Cavo, Michele ;
Ludwig, Heinz ;
Straka, Christian ;
Bringhen, Sara ;
Auner, Holger W. ;
Caers, Jo ;
Gramatzki, Martin ;
Offidani, Massimo ;
Dimopoulos, Meletios A. ;
Einsele, Hermann ;
Boccadoro, Mario ;
Sonneveld, Pieter ;
Engelhardt, Monika .
LEUKEMIA, 2018, 32 (08) :1697-1712
[7]  
Mina Roberto, 2019, Am Soc Clin Oncol Educ Book, V39, P500, DOI 10.1200/EDBK_239067
[8]   Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report [J].
Palumbo, Antonio ;
Bringhen, Sara ;
Mateos, Maria-Victoria ;
Larocca, Alessandra ;
Facon, Thierry ;
Kumar, Shaji K. ;
Offidani, Massimo ;
McCarthy, Philip ;
Evangelista, Andrea ;
Lonial, Sagar ;
Zweegman, Sonja ;
Musto, Pellegrino ;
Terpos, Evangelos ;
Belch, Andrew ;
Hajek, Roman ;
Ludwig, Heinz ;
Stewart, A. Keith ;
Moreau, Philippe ;
Anderson, Kenneth ;
Einsele, Hermann ;
Durie, Brian G. M. ;
Dimopoulos, Meletios A. ;
Landgren, Ola ;
San Miguel, Jesus F. ;
Richardson, Paul ;
Sonneveld, Pieter ;
Rajkumar, S. Vincent .
BLOOD, 2015, 125 (13) :2068-2074
[9]   Determining treatment intensity in elderly patients with multiple myeloma [J].
Salvini, Marco ;
D'Agostino, Mattia ;
Bonello, Francesca ;
Boccadoro, Mario ;
Bringhen, Sara .
EXPERT REVIEW OF ANTICANCER THERAPY, 2018, 18 (09) :917-930
[10]   Efficacy and Tolerability of Ixazomib, Daratumumab and Low Dose Dexamethasone (Ixa Dara dex) in Unfit and Frail Newly Diagnosed Multiple Myeloma (NDMM) Patients; Results of the Interim Efficacy Analysis of the Phase II HOVON 143 Study [J].
Stege, Claudia A. M. ;
Nasserinejad, Kazem ;
van der Spek, Ellen ;
Van Kampen, Roel J. W. ;
Sohne, Maaike ;
Thielen, Noortje ;
Bilgin, Yavuz ;
De Waal, Esther G. M. ;
Ludwig, Inge ;
Leijs, Maria B. L. ;
Kentos, Alain ;
Timmers, Gert Jan ;
de Heer, Koen ;
Westerman, Matthijs ;
Vekemans, Marie Christiane ;
Durdu-Rayman, Nazik ;
van der Burg-de Graauw, Nicole C. H. P. ;
Van de Donk, Niels W. C. J. ;
Sonneveld, Pieter ;
Klein, Saskia K. ;
Levin, Mark-David ;
Zweegman, Sonja .
BLOOD, 2019, 134