The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population

被引:8
作者
Nimgaonkar, Ila [1 ]
Valeri, Linda [2 ]
Susser, Ezra [3 ,4 ]
Hussain, Sabiha [5 ]
Sunderram, Jag [5 ]
Aviv, Abraham [6 ]
机构
[1] Rutgers State Univ, Robert Wood Johnson Med Sch, New Brunswick, NJ 08901 USA
[2] Columbia Univ, Mailman Sch Publ Hlth, Dept Biostat, New York, NY 10032 USA
[3] Columbia Univ, Mailman Sch Publ Hlth, New York, NY 10032 USA
[4] New York State Psychiat Inst & Hosp, New York, NY 10032 USA
[5] Rutgers State Univ, Robert Wood Johnson Med Sch, Dept Med, New Brunswick, NJ 08901 USA
[6] Rutgers State Univ, Ctr Human Dev & Aging, New Jersey Med Sch, Newark, NJ 07103 USA
来源
AGING-US | 2021年 / 13卷 / 03期
关键词
COVID-19; mortality; age; sex; cardiovascular disease; LEFT-VENTRICULAR HYPERTROPHY; SEX-DIFFERENCES; 1918; INFLUENZA; UNITED-STATES; X-CHROMOSOME; ACE2; GENE; SUSCEPTIBILITY; CENTENARIANS; HYPERTENSION; SARS-COV-2;
D O I
10.18632/aging.202639
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Males are at a higher risk of dying from COVID-19 than females. Older age and cardiovascular disease are also associated with COVID-19 mortality. To better understand how age and sex interact (in) contributing to COVID-19 mortality, we stratified the male-to-female (sex) ratios in mortality by age group. We then compared the age-stratified sex ratios with those of cardiovascular mortality and cancer mortality in the general population. Data were obtained from official government sources in the US and five European countries: Italy, Spain, France, Germany, and the Netherlands. The sex ratio of deaths from COVID-19 exceeded one throughout adult life, increasing up to a peak in midlife, and declining markedly in later life. This pattern was also observed for the sex ratio of deaths from cardiovascular disease, but not cancer, in the general populations of the US and European countries. Therefore, the sex ratios of deaths from COVID-19 and from cardiovascular disease share similar patterns across the adult life course. The underlying mechanisms are poorly understood and warrant further investigation.
引用
收藏
页码:3190 / 3201
页数:12
相关论文
共 38 条
  • [1] Ebola Virus Disease among Male and Female Persons in West Africa
    Agua-Agum, Junerlyn
    Ariyarajah, Archchun
    Blake, Isobel M.
    Cori, Anne
    Donnelly, Christl A.
    Dorigatti, Ilaria
    Dye, Christopher
    Eck-Manns, Tim
    Ferguson, Neil M.
    Fraser, Christophe
    Garske, Tini
    Hinsley, Wes
    Jombart, Thibaut
    Mills, Harriet L.
    Nedjati-Gilani, Gemma
    Newton, Emily
    Nouvellet, Pierre
    Perkins, Devin
    Riley, Steven
    Schumacher, Dirk
    Shah, Anita
    Thomas, Lisa J.
    Van Kerkhove, Maria D.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2016, 374 (01) : 96 - 98
  • [2] Becoming Centenarians: Disease and Functioning Trajectories of Older US Adults as They Survive to 100
    Ailshire, Jennifer A.
    Beltran-Sanchez, Hiram
    Crimmins, Eileen M.
    [J]. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 2015, 70 (02): : 193 - 201
  • [3] ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy
    Asselta, Rosanna
    Paraboschi, Elvezia Maria
    Mantovani, Alberto
    Duga, Stefano
    [J]. AGING-US, 2020, 12 (11): : 10087 - 10098
  • [4] Bautista E, 2010, NEW ENGL J MED, V362, P1708, DOI 10.1056/NEJMra1000449
  • [5] Coronavirus Disease 2019 in Children - United States, February 12-April 2, 2020
    Bialek, Stephanie
    Gierke, Ryan
    Hughes, Michelle
    McNamara, Lucy A.
    Pilishvili, Tamara
    Skoff, Tami
    [J]. MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2020, 69 (14): : 422 - 426
  • [6] From causes of aging to death from COVID-19
    Blagosklonny, Mikhail V.
    [J]. AGING-US, 2020, 12 (11): : 10004 - 10021
  • [7] Sex differences in coronary heart disease and stroke mortality: a global assessment of the effect of ageing between 1980 and 2010
    Bots, Sophie H.
    Peters, Sanne A. E.
    Woodward, Mark
    [J]. BMJ GLOBAL HEALTH, 2017, 2 (02):
  • [8] Endogenous estrogens and the risk of breast, endometrial, and ovarian cancers
    Brown, Susan B.
    Hankinson, Susan E.
    [J]. STEROIDS, 2015, 99 : 8 - 10
  • [9] The ACE2 gene: its potential as a functional candidate for cardiovascular disease
    Burrell, Louise M.
    Harrap, Stephen B.
    Velkoska, Elena
    Patel, Sheila K.
    [J]. CLINICAL SCIENCE, 2013, 124 (1-2) : 65 - 76
  • [10] Center for Disease Control and Prevention, 2020, SOC DIST