Nitric oxide signaling in human ovarian cancer: A potential therapeutic target

被引：28
|
作者：
El-Sehemy, Ahmed [1 ,3 ]
Postovit, Lynne-Marie [1 ]
Fu, YangXin [1 ,2 ]
机构：
[1] Univ Alberta, Fac Med & Dent, Dept Oncol, Edmonton, AB T6G 2E1, Canada
[2] Univ Alberta, Fac Med & Dent, Dept Obstet & Gynecol, Edmonton, AB T6G 2E1, Canada
[3] Univ Toronto, Fac Med, Dept Lab Med & Pathobiol, Toronto, ON, Canada
来源：
NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2016年 / 54卷
关键词：
Nitric oxide; Ovarian cancer; iNOS; Diagnostic marker; Therapeutic target; CELL LUNG-CANCER; SOLUBLE GUANYLYL CYCLASE; RANDOMIZED PHASE-II; GAMMA GENE-THERAPY; S-NITROSYLATION; TUMORICIDAL ACTIVITY; ANTITUMOR-ACTIVITY; REGULATED KINASE; INTERFERON-BETA; TUMOR-CELLS;
D O I：
10.1016/j.niox.2016.02.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ovarian cancer is the leading cause of death due to gynecologic malignancies worldwide. Current therapy regimens are ineffective to treat advanced ovarian cancers, presenting a need to develop novel therapeutic strategies. Nitric oxide (NO) is a multifunctional gaseous molecule that is generated by cancer, stromal and endothelial cells and plays a multifaceted role in cancer biology through multiple mechanisms. Accumulating evidence suggests that NO signaling is involved in multiple aspects of ovarian cancer, including growth, apoptosis, cancer-stromal cell interaction, angiogenesis and response to chemotherapy. This review will discuss the experimental and clinical evidence of the involvement of NO signaling in ovarian cancer and the therapeutic potential of targeting NO signaling in ovarian cancer. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码：30 / 37
页数：8
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