Integrin and ECM functions - roles in vertebrate development

被引:178
作者
De Arcangelis, A [1 ]
Georges-Labouesse, E [1 ]
机构
[1] ULP, Inst Genet & Biol Mol & Cellulaire, CNRS, INSERM, F-67404 Illkirch Graffenstaden, France
关键词
D O I
10.1016/S0168-9525(00)02074-6
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The analysis of mutant mice is bringing navel insights on the role of extracellular matrix (ECM) and integrin receptors during a variety of physiological processes, including embryonic development. The requirement of these adhesion molecules in epithelial morphogenesis or histogenesis in organs such as kidneys and lungs, in limbs, and in the development of mesoderm and the nervous system has been unraveled by the study of single or compound mutants. Their role in tissue integrity has also been highlighted. Models have been produced that should prove very useful in defining the cellular mechanisms and the functions of integrins and ECM signaling cascades in vivo.
引用
收藏
页码:389 / 395
页数:7
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