A Study of Midazolam Plasma Concentrations in Patients Undergoing Conscious Sedation

被引:0
作者
Benedik, Janez [1 ]
Kozelj, Gordana [2 ]
Manohin, Aleksander [1 ]
机构
[1] Univ Med Ctr Ljubljana, Dept Anaesthet & Surg Intens Care, Ljubljana 1000, Slovenia
[2] Univ Ljubljana, Fac Med, Inst Forens Med, Ljubljana 61000, Slovenia
关键词
Midazolam; sedation; adults; surgery: middle ear; chromatography; mass spectrometry; INTENSIVE-CARE; PHARMACOKINETICS; ANESTHESIA; SCORE;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We studied midazolam plasma concentrations in patients undergoing middle ear surgery (MES) in local anesthesia and sedation. This study was based on the clinical measurement of the level of sedation and determination of the sedation dose of midazolam. For optimal level of sedation for this type of surgery we suggest the midazolam plasma concentrations with median of 0.03 mg L-1 and range from 0.01-0.10 mg L-1. This can be contrasted to the other studies where considerably higher plasma concentrations of midazolam (0.2 mg L-1) were proposed (S. Michalk et al., Intens. Care Med. 1988, 15, 37-41). Despite low midazolam concentrations the level of sedation was adequate.
引用
收藏
页码:206 / 211
页数:6
相关论文
共 50 条
  • [41] EFFICACY OF PROPOFOL AND MIDAZOLAM IN CONSCIOUS SEDATION FOR IMPLANT AND PERIODONTAL SURGERY
    Gupta, Amrita
    Gupta, Abhinav
    Saxena, Avanish
    Sharma, Parimal
    Srivastava, Uma
    Dwivedi, Yogita
    JOURNAL OF EVOLUTION OF MEDICAL AND DENTAL SCIENCES-JEMDS, 2012, 1 (06): : 1172 - 1177
  • [42] Use of midazolam and ketamine as sedation for children undergoing minor operative procedures
    D. K. L. Cheuk
    W. H. S. Wong
    E. Ma
    T. L. Lee
    S. Y. Ha
    Y. L. Lau
    G. C. F. Chan
    Supportive Care in Cancer, 2005, 13 : 1001 - 1009
  • [43] Midazolam effectiveness in conscious sedation:: Intrauasal and oral routes.
    Castro, E
    Díaz, M
    Valdivieso, M
    JOURNAL OF DENTAL RESEARCH, 2003, 82 : 593 - 593
  • [44] Effect of midazolam on cardiopulmonary function during colonoscopy with conscious sedation
    Kim, Young Hoon
    Kim, Ji Won
    Lee, Kook Lae
    Joo, Sae Kyung
    Lee, Jaekyung
    Koh, Seong-Joon
    Kim, Byeong Gwan
    Park, Chan-Kuk
    DIGESTIVE ENDOSCOPY, 2014, 26 (03) : 417 - 423
  • [45] Memory in pediatric patients undergoing conscious sedation for aversive medical procedures
    Pringle, B
    Dahlquist, LM
    Eskenazi, A
    HEALTH PSYCHOLOGY, 2003, 22 (03) : 263 - 269
  • [46] Use of midazolam and ketamine as sedation for children undergoing minor operative procedures
    Cheuk, DKL
    Wong, WHS
    Ma, E
    Lee, TL
    Ha, SY
    Lau, YL
    Chan, GCF
    SUPPORTIVE CARE IN CANCER, 2005, 13 (12) : 1001 - 1009
  • [47] Comparison the sedation effect and satisfaction of two combinations, dexmedetomidine and fentanyl with midazolam and fentanyl, in patients undergoing bronchoscopy
    Karnali, Alireza
    Sarkhosh, Sepideh
    Kazemizadeh, Hosein
    JOURNAL OF CONTEMPORARY MEDICAL SCIENCES, 2020, 6 (06): : 296 - 299
  • [48] Possibility of influence of midazolam sedation on the diagnosis of brain death: Concentrations of active metabolites after cessation of midazolam
    Hirata, K
    Matsumoto, Y
    Kurokawa, A
    Onda, M
    Shimizu, M
    Fukuoka, M
    Hirano, M
    Yamamoto, Y
    YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2003, 123 (09): : 811 - 815
  • [49] COMPARISON OF PROPOFOL AND MIDAZOLAM FOR SEDATION IN INTENSIVE-CARE UNIT PATIENTS
    RONAN, KP
    GALLAGHER, TJ
    GEORGE, B
    HAMBY, B
    CRITICAL CARE MEDICINE, 1995, 23 (02) : 286 - 293
  • [50] Initial Experience Assessing the Feasibility of Conscious Sedation in Patients Undergoing Transcatheter Pulmonic Valve Implantation
    Anchan, Rajeev
    Weibeler, Diane
    Venturini, Joseph M.
    Dia, AbdulRahman
    Gruenstein, Daniel H.
    Shahul, Sajid S.
    Kalathiya, Rohan
    Blair, John
    Paul, Jonathan D.
    Nathan, Sandeep
    Friant, Janet
    Besser, Stephanie A.
    Shah, Atman P.
    STRUCTURAL HEART-THE JOURNAL OF THE HEART TEAM, 2021, 5 (03): : 302 - 311