A Study of Midazolam Plasma Concentrations in Patients Undergoing Conscious Sedation

被引：0
作者：
Benedik, Janez [1 ]
Kozelj, Gordana [2 ]
Manohin, Aleksander [1 ]
机构：
[1] Univ Med Ctr Ljubljana, Dept Anaesthet & Surg Intens Care, Ljubljana 1000, Slovenia
[2] Univ Ljubljana, Fac Med, Inst Forens Med, Ljubljana 61000, Slovenia
来源：
ACTA CHIMICA SLOVENICA | 2010年 / 57卷 / 01期
关键词：
Midazolam; sedation; adults; surgery: middle ear; chromatography; mass spectrometry; INTENSIVE-CARE; PHARMACOKINETICS; ANESTHESIA; SCORE;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We studied midazolam plasma concentrations in patients undergoing middle ear surgery (MES) in local anesthesia and sedation. This study was based on the clinical measurement of the level of sedation and determination of the sedation dose of midazolam. For optimal level of sedation for this type of surgery we suggest the midazolam plasma concentrations with median of 0.03 mg L-1 and range from 0.01-0.10 mg L-1. This can be contrasted to the other studies where considerably higher plasma concentrations of midazolam (0.2 mg L-1) were proposed (S. Michalk et al., Intens. Care Med. 1988, 15, 37-41). Despite low midazolam concentrations the level of sedation was adequate.
引用
收藏
页码：206 / 211
页数：6
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