Stealth nanorods via the aqueous living crystallisation-driven self-assembly of poly(2-oxazoline)s

被引：45

作者：

Finnegan, John R. ^{[1
]}

Pilkington, Emily H. ^{[1
,2
]}

Alt, Karen ^{[3
]}

Rahim, Md. Arifur ^{[4
]}

Kent, Stephen J. ^{[2
]}

Davis, Thomas P. ^{[1
,5
]}

Kempe, Kristian ^{[1
,6
]}

机构：

[1] Monash Univ, Monash Inst Pharmaceut Sci, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, ARC Ctr Excellence Convergent Bionano Sci, Parkville, Vic 3010, Australia

[3] Monash Univ, Australian Ctr Blood Dis, NanoTheranost Lab, Melbourne, Vic 3004, Australia

[4] Univ New South Wales UNSW, Sch Chem Engn, Sydney, NSW 2052, Australia

[5] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

[6] Monash Univ, Mat Sci & Engn, Clayton, Vic 3800, Australia

来源：

CHEMICAL SCIENCE | 2021年 / 12卷 / 21期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

K. K. gratefully acknowledges the award of an ARC Future Fellowship (FT190100572) from the Australian Research Council (ARC). K. A. is supported by the National Health and Medical Research Council of Australia (Career Development Fellowship GNT1140465). This work was – in part – carried out within the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). We would like to thank the Bio21 Advanced Microscopy Facility (University of Melbourne) and Prof. Patrick Sexton (Monash University) for access to their electron microscopy facilities. Finally; the authors acknowledge the use of the facilities and the assistance of Dr Jisheng Ma at the Monash X-ray Platform; as well as the support provided to this project by the HMS Trust Laboratory; based at the Monash Institute of Pharmaceutical Sciences.K. K. gratefully acknowledges the award of an ARC Future Fellowship (FT190100572) from the Australian Research Council (ARC). K. A. is supported by the National Health and Medical Research Council of Australia (Career Development Fellowship GNT1140465). This work was - in part - carried out within the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (Project No. CE140100036). We would like to thank the Bio21 Advanced Microscopy Facility (University of Melbourne) and Prof. Patrick Sexton (Monash University) for access to their electron microscopy facilities. Finally; based at the Monash Institute of Pharmaceutical Sciences;

D O I：

10.1039/d1sc00938a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The morphology of nanomaterials critically influences their biological interactions. However, there is currently a lack of robust methods for preparing non-spherical particles from biocompatible materials. Here, we combine 'living' crystallisation-driven self-assembly (CDSA), a seeded growth method that enables the preparation of rod-like polymer nanoparticles, with poly(2-oxazoline)s (POx), a polymer class that exhibits 'stealth' behaviour and excellent biocompatibility. For the first time, the 'living' CDSA process was carried out in pure water, resulting in POx nanorods with lengths ranging from similar to 60 to 635 nm. In vitro and in vivo study revealed low immune cell association and encouraging blood circulation times, but little difference in the behaviour of POx nanorods of different length. The stealth behaviour observed highlights the promising potential of POx nanorods as a next generation stealth drug delivery platform.

引用

页码：7350 / 7360

页数：11

共 67 条

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