Bisdemethoxycurcumin loaded polymeric mixed micelles as potential anti-cancer remedy: Preparation, optimization and cytotoxic evaluation in a HepG-2 cell model

被引：51

作者：

Mehanny, Mina ^{[1
]}

Hathout, Rania M. ^{[1
]}

Geneidi, Ahmed S. ^{[1
]}

Mansour, Samar ^{[1
,2
]}

机构：

[1] Ain Shams Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, African Union Org St,POB 11566, Cairo, Egypt

[2] German Univ Cairo, Fac Pharm & Biotechnol, Dept Pharmaceut Technol, Cairo, Egypt

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2016年 / 214卷

关键词：

MARKOV-CHAIN MODEL; IN-VITRO; BLOCK-COPOLYMERS; DRUG-DELIVERY; MACROMOLECULAR THERAPEUTICS; PLGA NANOPARTICLES; CANCER; CURCUMIN; VIVO; TUMOR;

D O I：

10.1016/j.molliq.2015.12.007

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The purpose of this study was to prepare and optimize Pluronic (R) mixed micelles as nanocarriers for a natural curcumin derivative viz. bisdemethoxycurcumin (BDMC) that can be used in cancer treatment. Different formulations were prepared according to a full-factorial statistical design. Hence, four mathematical models were generated for the responses; particle size, polydispersity index, zeta-potential and entrapment efficiency percentage. The ratio 20%:80% (F68:F127) w:w and utilizing acetone solely in micellar preparation using thin-film hydration scored optimum results regarding the aforementioned responses. In evaluating the cytotoxic effect of these newly prepared BDMC systems on HepG-2 model cancer cells, an IC50 of 0.74 mu g/ml was obtained which propose polymeric mixed micelles as successful anti-cancer nanocarrier systems. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：162 / 170

页数：9

共 4 条

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