Plasma osteoprotegerin concentrations in peripheral sensory neuropathy in Type 1 and Type 2 diabetic patients

被引:20
作者
Nybo, M. [1 ]
Poulsen, M. K. [2 ]
Grauslund, J. [3 ]
Henriksen, J. E. [2 ]
Rasmussen, L. M. [1 ]
机构
[1] Odense Univ Hosp, Dept Biochem & Pharmacol, DK-5000 Odense, Denmark
[2] Odense Univ Hosp, Dept Endocrinol, Diabet Res Ctr, DK-5000 Odense, Denmark
[3] Odense Univ Hosp, Dept Ophthalmol, DK-5000 Odense, Denmark
关键词
biochemical markers; diabetes; neuropathy; osteoprotegerin; KAPPA-B LIGAND; RECEPTOR ACTIVATOR; BONE-DENSITY; INSULIN; MELLITUS; SERUM; ASSOCIATION; MORTALITY; DISEASE; DENMARK;
D O I
10.1111/j.1464-5491.2010.02940.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
P>Aims Osteoprotegerin (OPG) has been linked to different diabetes complications, including cardiovascular disease, and new findings have indicated a specific role in diabetic peripheral neuropathy, but the exact mechanism is unknown. To investigate a possible association between OPG and diabetic peripheral sensory neuropathy, we therefore analysed plasma OPG in Type 1 and Type 2 diabetic patients with and without peripheral neuropathy. Subjects and methods Two hundred Type 1 diabetes mellitus (T1DM) patients and 305 Type 2 diabetes mellitus (T2DM) patients participated in the study. Plasma OPG was measured with a sandwich immunoassay. Peripheral neuropathy was assessed by the Semmes-Weinstein monofilament test. Results In T2DM, plasma OPG concentrations were significantly higher in the peripheral neuropathy group (P < 0.001). Furthermore, there was a significant relationship between the presence of neuropathy in T2DM and plasma OPG levels on logistic regression (P = 0.006). However, when investigated in a full multiple regression model including other long-term diabetes complications, the association became insignificant (P = 0.092). In T1DM, the difference in plasma OPG between groups did not reach significance (P = 0.066). However, plasma OPG significantly correlated to peripheral neuropathy in this group also (P = 0.022), although this correlation was not significant in a multiple linear regression model (P = 0.051). Conclusion Plasma OPG levels are related to peripheral neuropathy in both Type 1 and Type 2 diabetes, although with the strongest relationship in T2DM. Before understanding the significance of this, the pathological mechanism involved and, speculatively, a possible use of plasma OPG as a peripheral sensory neuropathy marker, a larger prospective study is needed.
引用
收藏
页码:289 / 294
页数:6
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