Semiconductor Nanorod-Carbon Nanotube Biomimetic Films for Wire-Free Photostimulation of Blind Retinas

被引:98
作者
Bareket, Lilach [1 ,2 ]
Waiskopf, Nir [4 ,5 ]
Rand, David [1 ,2 ]
Lubin, Gur [1 ,2 ]
David-Pur, Moshe [1 ,2 ]
Ben-Dov, Jacob [1 ,2 ]
Roy, Soumyendu [1 ,2 ]
Eleftheriou, Cyril [6 ]
Sernagor, Evelyne [6 ]
Cheshnovsky, Ori [2 ,3 ]
Banin, Uri [4 ,5 ]
Hanein, Yael [1 ,2 ]
机构
[1] Tel Aviv Univ, Sch Elect Engn, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Univ, Ctr Nanosci & Nanotechnol, IL-69978 Tel Aviv, Israel
[3] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel
[4] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel
[5] Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel
[6] Newcastle Univ, Fac Med Sci, Inst Neurosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
基金
欧洲研究理事会; 英国生物技术与生命科学研究理事会;
关键词
Neural photostimulation; carbon nanotubes; quantum rods; retinal implant; neural prosthesis; plasma polymerization; QUANTUM DOTS; MULTIELECTRODE ARRAY; BRAIN-STIMULATION; CHARGE-TRANSFER; LIGHT; CHICK; INTERFACE; CELLS; EXPRESSION; SYSTEM;
D O I
10.1021/nl5034304
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
We report the development of a semiconductor nanorod-carbon nanotube based platform for wire-free, light induced retina stimulation. A plasma polymerized acrylic acid midlayer was used to achieve covalent conjugation of semiconductor nanorods directly onto neuro-adhesive, three-dimensional carbon nanotube surfaces. Photocurrent, photovoltage, and fluorescence lifetime measurements validate efficient charge transfer between the nanorods and the carbon nanotube films. Successful stimulation of a light-insensitive chick retina suggests the potential use of this novel platform in future artificial retina applications.
引用
收藏
页码:6685 / 6692
页数:8
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