Semiconductor Nanorod-Carbon Nanotube Biomimetic Films for Wire-Free Photostimulation of Blind Retinas

被引：99

作者：

Bareket, Lilach ^{[1
,2
]}

Waiskopf, Nir ^{[4
,5
]}

Rand, David ^{[1
,2
]}

Lubin, Gur ^{[1
,2
]}

David-Pur, Moshe ^{[1
,2
]}

Ben-Dov, Jacob ^{[1
,2
]}

Roy, Soumyendu ^{[1
,2
]}

Eleftheriou, Cyril ^{[6
]}

Sernagor, Evelyne ^{[6
]}

Cheshnovsky, Ori ^{[2
,3
]}

Banin, Uri ^{[4
,5
]}

Hanein, Yael ^{[1
,2
]}

机构：

[1] Tel Aviv Univ, Sch Elect Engn, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, Ctr Nanosci & Nanotechnol, IL-69978 Tel Aviv, Israel

[3] Tel Aviv Univ, Sch Chem, IL-69978 Tel Aviv, Israel

[4] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel

[5] Hebrew Univ Jerusalem, Ctr Nanosci & Nanotechnol, IL-91904 Jerusalem, Israel

[6] Newcastle Univ, Fac Med Sci, Inst Neurosci, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

来源：

NANO LETTERS | 2014年 / 14卷 / 11期

基金：

英国生物技术与生命科学研究理事会; 欧洲研究理事会;

关键词：

Neural photostimulation; carbon nanotubes; quantum rods; retinal implant; neural prosthesis; plasma polymerization; QUANTUM DOTS; MULTIELECTRODE ARRAY; BRAIN-STIMULATION; CHARGE-TRANSFER; LIGHT; CHICK; INTERFACE; CELLS; EXPRESSION; SYSTEM;

D O I：

10.1021/nl5034304

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the development of a semiconductor nanorod-carbon nanotube based platform for wire-free, light induced retina stimulation. A plasma polymerized acrylic acid midlayer was used to achieve covalent conjugation of semiconductor nanorods directly onto neuro-adhesive, three-dimensional carbon nanotube surfaces. Photocurrent, photovoltage, and fluorescence lifetime measurements validate efficient charge transfer between the nanorods and the carbon nanotube films. Successful stimulation of a light-insensitive chick retina suggests the potential use of this novel platform in future artificial retina applications.

引用

页码：6685 / 6692

页数：8

共 54 条

[1]

[Anonymous], BIOPHOTONICS

[2] Novel interfaces for light directed neuronal stimulation: advances and challenges [J].

Bareket-Keren, Lilach ;

Hanein, Yael .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2014, 9 :65-83

[3] Carbon nanotube-based multielectrode arrays for neuronal interfacing: progress and prospects [J].

Bareket-Keren, Lilach ;

Hanein, Yael .

FRONTIERS IN NEURAL CIRCUITS, 2013, 6

[4] Ectopic expression of a microbial-type rhodopsin restores visual responses in mice with photoreceptor degeneration [J].

Bi, AD ;

Cui, JJ ;

Ma, YP ;

Olshevskaya, E ;

Pu, ML ;

Dizhoor, AM ;

Pan, ZH .

NEURON, 2006, 50 (01) :23-33

[5]

Bruhn SL, 1996, J NEUROSCI, V16, P1430

[6] Synthesis and micrometer-scale assembly of colloidal CdSe/CdS nanorods prepared by a seeded growth approach [J].

Carbone, Luigi ;

Nobile, Concetta ;

De Giorgi, Milena ;

Sala, Fabio Delia ;

Morello, Giovanni ;

Pompa, Pierpaolo ;

Hytch, Martin ;

Snoeck, Etienne ;

Fiore, Angela ;

Franchini, Isabella R. ;

Nadasan, Monica ;

Silvestre, Albert F. ;

Chiodo, Letizia ;

Kudera, Stefan ;

Cingolani, Roberto ;

Krahne, Roman ;

Manna, Liberato .

NANO LETTERS, 2007, 7 (10) :2942-2950

[7] CdSe quantum dots induce apoptosis in human neuroblastoma cells via mitochondrial-dependent pathways and inhibition of survival signals [J].

Chan, Wen-Hsiung ;

Shiao, Nion-Heng ;

Lu, Pin-Zhen .

TOXICOLOGY LETTERS, 2006, 167 (03) :191-200

[8] The artificial silicon retina microchip for the treatment of vision loss from retinitis pigmentosa [J].

Chow, AY ;

Chow, VY ;

Packo, KH ;

Pollack, JS ;

Peyman, GA ;

Schuchard, R .

ARCHIVES OF OPHTHALMOLOGY, 2004, 122 (04) :460-469

[9] The multiple-channel cochlear implant: the interface between sound and the central nervous system for hearing, speech, and language in deaf people - a personal perspective [J].

Clark, Graeme M. .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2006, 361 (1469) :791-810

[10] Neural stimulation and recording electrodes [J].

Cogan, Stuart F. .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2008, 10 :275-309

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