The quasispecies nature and biological implications of the hepatitis C virus

被引：53

作者：

Fishman, Sarah L. ^{[1
]}

Branch, Andrea D. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Med, Div Liver Dis, New York, NY 10029 USA

来源：

INFECTION GENETICS AND EVOLUTION | 2009年 / 9卷 / 06期

关键词：

HCV; Quasispecies; RNA; Consensus sequence; Viral persistence; Compartmentalization; Interferon resistance; Diversity; Complexity; HUMAN-IMMUNODEFICIENCY-VIRUS; BLOOD MONONUCLEAR-CELLS; HYPERVARIABLE REGION 1; MOUTH-DISEASE VIRUS; SENSITIVITY-DETERMINING REGION; VESICULAR STOMATITIS-VIRUS; TO-INFANT TRANSMISSION; CENTRAL-NERVOUS-SYSTEM; GEL SHIFT ANALYSIS; INTERFERON THERAPY;

D O I：

10.1016/j.meegid.2009.07.011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Many RNA viruses exist as a cloud of closely related sequence variants called a quasispecies, rather than as a population of identical clones. In this article, we explain the quasispecies nature of RNA viral genomes, and briefly review the principles of quasispecies dynamics and the differences with classical population genetics. We then discuss the current methods for quasispecies analysis and conclude with the biological implications of this phenomenon, focusing on the hepatitis C virus. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1158 / 1167

页数：10

共 151 条

[51] Tracking hepatitis C virus quasispecies major and minor variants in symptomatic and asymptomatic liver transplant recipients [J].

Gretch, DR ;

Polyak, SJ ;

Wilson, JJ ;

Carithers, RL ;

Perkins, JD ;

Corey, L .

JOURNAL OF VIROLOGY, 1996, 70 (11) :7622-7631

[52]

GRETCH DR, 1997, HEPATITIS C VIRUS GE

[53] Differences in epidemiology, liver disease and treatment response among HCV genotypes [J].

Hadziyannis, SJ ;

Koskinas, JS .

HEPATOLOGY RESEARCH, 2004, 29 (03) :129-135

[54] Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection [J].

Hayashi, J ;

Kishihara, Y ;

Yamaji, K ;

Furusyo, N ;

Yamamoto, T ;

Pae, Y ;

Etoh, Y ;

Ikematsu, H ;

Kashiwagi, S .

HEPATOLOGY, 1997, 25 (03) :697-701

[55] HOW SENSITIVE IS PCR-SSCP [J].

HAYASHI, K ;

YANDELL, DW .

HUMAN MUTATION, 1993, 2 (05) :338-346

[56]

Hayashi K, 1991, PCR Methods Appl, V1, P34

[57] Relative replication capacity and selective advantage profiles of protease inhibitor-resistant hepatitis C virus (HCV) NS3 protease mutants in the HCV genotype 1b replicon system [J].

He, Yupeng ;

King, Martin S. ;

Kempf, Dale J. ;

Lu, Liangjun ;

Ben Lim, Hock ;

Krishnan, Preethi ;

Kati, Warren ;

Middleton, Timothy ;

Molla, Akhteruzzaman .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (03) :1101-1110

[58] Wide range of quasispecies diversity during primary hepatitis C virus infection [J].

Herring, BL ;

Tsui, R ;

Peddada, L ;

Busch, M ;

Delwart, EL .

JOURNAL OF VIROLOGY, 2005, 79 (07) :4340-4346

[59] DNA bar coding and pyrosequencing to identify rare HIV drug resistance mutations [J].

Hoffmann, Christian ;

Minkah, Nana ;

Leipzig, Jeremy ;

Wang, Gary ;

Arens, Max Q. ;

Tebas, Pablo ;

Bushman, Frederic D. .

NUCLEIC ACIDS RESEARCH, 2007, 35 (13)

[60] MUTATION FREQUENCIES AT DEFINED SINGLE CODON SITES IN VESICULAR STOMATITIS-VIRUS AND POLIOVIRUS CAN BE INCREASED ONLY SLIGHTLY BY CHEMICAL MUTAGENESIS [J].

HOLLAND, JJ ;

DOMINGO, E ;

DELATORRE, JC ;

STEINHAUER, DA .

JOURNAL OF VIROLOGY, 1990, 64 (08) :3960-3962

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