The quasispecies nature and biological implications of the hepatitis C virus

被引：53

作者：

Fishman, Sarah L. ^{[1
]}

Branch, Andrea D. ^{[1
]}

机构：

[1] Mt Sinai Sch Med, Dept Med, Div Liver Dis, New York, NY 10029 USA

来源：

INFECTION GENETICS AND EVOLUTION | 2009年 / 9卷 / 06期

关键词：

HCV; Quasispecies; RNA; Consensus sequence; Viral persistence; Compartmentalization; Interferon resistance; Diversity; Complexity; HUMAN-IMMUNODEFICIENCY-VIRUS; BLOOD MONONUCLEAR-CELLS; HYPERVARIABLE REGION 1; MOUTH-DISEASE VIRUS; SENSITIVITY-DETERMINING REGION; VESICULAR STOMATITIS-VIRUS; TO-INFANT TRANSMISSION; CENTRAL-NERVOUS-SYSTEM; GEL SHIFT ANALYSIS; INTERFERON THERAPY;

D O I：

10.1016/j.meegid.2009.07.011

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Many RNA viruses exist as a cloud of closely related sequence variants called a quasispecies, rather than as a population of identical clones. In this article, we explain the quasispecies nature of RNA viral genomes, and briefly review the principles of quasispecies dynamics and the differences with classical population genetics. We then discuss the current methods for quasispecies analysis and conclude with the biological implications of this phenomenon, focusing on the hepatitis C virus. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1158 / 1167

页数：10

共 151 条

[1] Nonrandom distribution of hepatitis C virus quasispecies in plasma and peripheral blood mononuclear cell subsets [J].

Afonso, AMR ;

Jiang, JJ ;

Penin, F ;

Tareau, C ;

Samuel, D ;

Petit, MA ;

Bismuth, H ;

Dussaix, E ;

Féray, C .

JOURNAL OF VIROLOGY, 1999, 73 (11) :9213-9221

[2] Curing of foot-and-mouth disease virus from persistently infected cells by ribavirin involves enhanced mutagenesis [J].

Airaksinen, A ;

Pariente, N ;

Menéndez-Arias, L ;

Domingo, E .

VIROLOGY, 2003, 311 (02) :339-349

[3] Viral error catastrophe by mutagenic nucleosides [J].

Anderson, JP ;

Daifuku, R ;

Loeb, LA .

ANNUAL REVIEW OF MICROBIOLOGY, 2004, 58 :183-205

[4] Hepatitis C virus quasi-species dynamics predict progression of fibrosis after liver transplantation [J].

Arenas, JI ;

Gallegos-Orozco, JF ;

Laskus, T ;

Wilkinson, J ;

Khatib, A ;

Fasola, C ;

Adair, D ;

Radkowski, M ;

Kibler, KV ;

Nowicki, M ;

Douglas, D ;

Williams, J ;

Netto, G ;

Mulligan, D ;

Klintmalm, G ;

Rakela, J ;

Vargas, HE .

JOURNAL OF INFECTIOUS DISEASES, 2004, 189 (11) :2037-2046

[5] Natural prevalence of hepatitis C virus variants with decreased sensitivity to NS3•4A protease inhibitors in treatment-naive subjects [J].

Bartels, Doug J. ;

Zhou, Yi ;

Zhang, Eileen Z. ;

Marcial, Michelle ;

Byrn, Randal A. ;

Pfeiffer, Thomas ;

Tigges, Ann M. ;

Adiwijaya, Bambang S. ;

Lin, Chao ;

Kwong, Ann D. ;

Kieffer, Tara L. .

JOURNAL OF INFECTIOUS DISEASES, 2008, 198 (06) :800-807

[6] The error threshold [J].

Biebricher, CK ;

Eigen, M .

VIRUS RESEARCH, 2005, 107 (02) :117-127

[7] DISTINCT REPERTOIRE OF ANTIGENIC VARIANTS OF FOOT-AND-MOUTH-DISEASE VIRUS IN THE PRESENCE OR ABSENCE OF IMMUNE SELECTION [J].

BORREGO, B ;

NOVELLA, IS ;

GIRALT, E ;

ANDREU, D ;

DOMINGO, E .

JOURNAL OF VIROLOGY, 1993, 67 (10) :6071-6079

[8] GENETIC-HETEROGENEITY OF HEPATITIS-C VIRUS - QUASI-SPECIES AND GENOTYPES [J].

BUKH, J ;

MILLER, RH ;

PURCELL, RH .

SEMINARS IN LIVER DISEASE, 1995, 15 (01) :41-63

[9] Quasispecies made simple [J].

Bull, JJ ;

Meyers, LA ;

Lachmann, M .

PLOS COMPUTATIONAL BIOLOGY, 2005, 1 (06) :450-460

[10] Nucleotide and amino acid complexity of hepatitis C virus quasispecies in serum and liver [J].

Cabot, B ;

Martell, M ;

Esteban, JI ;

Sauleda, S ;

Otero, T ;

Esteban, R ;

Guàrdia, J ;

Gómez, J .

JOURNAL OF VIROLOGY, 2000, 74 (02) :805-811

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