Solventless lactam synthesis by intramolecular cyclizations of α-iminoester derivatives under microwave irradiation

被引：4

作者：

Zradni, Fatima-Zohra ^{[1
]}

Hamelin, Jack

Derdour, Aicha

机构：

[1] Univ Essenia, Fac Sci, Dept Chim, Oran, Algeria

[2] Univ Rennes 1, Grp Ingn Chim & Mol Vivant 3, IVMV3, UMR 6226, F-35042 Rennes, France

来源：

MOLECULES | 2007年 / 12卷 / 03期

关键词：

medium-sized ring lactams; imme alkylation; Schiff bases; microwave irradiation;

D O I：

10.3390/12030439

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously reported a new synthesis of amides from esters and amines under microwave irradiation, offering much higher yields than those achieved with conventional heating [1]. We have now extended these studies to the ring closure of neat iminoesters 12, 13 and 14-16 to give five- and six-membered ring lactams L5, L6 and larger lactams L7-L9 (where I means imine and L means lactam), respectively, under both classical heating conditions and microwave irradiation.

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收藏

页码：439 / 454

页数：16

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