Research progress on the role of connective tissue growth factor in fibrosis of diabetic retinopathy

被引：15

作者：

Ma, Teng ^{[1
]}

Dong, Li-Jie ^{[1
]}

Du, Xue-Li ^{[1
]}

Niu, Rui ^{[1
]}

Hu, Bo-Jie ^{[1
]}

机构：

[1] Tianjin Med Univ, Ophthalmol Coll, Eye Inst, Eye Hosp, Tianjin 300384, Peoples R China

来源：

INTERNATIONAL JOURNAL OF OPHTHALMOLOGY | 2018年 / 11卷 / 09期

关键词：

proliferative diabetic retinopathy; fibrosis; connective tissue growth factor; vascular endothelial growth factor; INTRAVITREAL BEVACIZUMAB; CHOROIDAL NEOVASCULARIZATION; EXTRACELLULAR-MATRIX; CTGF; CELLS; EXPRESSION; INJECTION; MIGRATION; GLAUCOMA; RETINA;

D O I：

10.18240/ijo.2018.09.20

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Diabetic retinopathy (DR) is one of the most important types of diabetic microangiopathy, which is a specific change of fundus lesions and is one of the most serious complications of diabetes. When DR develops to proliferative DR, the main factors of decreasing vision, and even blindness, include retinal detachment and vitreous hemorrhage caused by contraction of blood vessels by fiber membrane. Recent studies reported that the formation of fiber vascular membrane is closely related to retinal fibrosis. The connective tissue growth factor (CTGF) is a cytokine that is closely related to DR fibrosis. However, its mechanism is poorly understood. This paper summarizes the recent studies about CTGF on DR fibrosis for a comprehensive understanding of the role and mechanism of CTGF in PDR.

引用

页码：1550 / 1554

页数：5

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