The C1167T polymorphism of the catalase gene and polymorphic markers D11S907 and D11S2008 located in its vicinity are associated with diabetes mellitus type 2

被引：3

作者：

Chistyakov, DA ^{[1
]}

Savost'yanov, KV

Turakulov, RI

Scherbacheva, LN

Mamaeva, GG

Balabolkin, MI

Nosikov, VV

机构：

[1] State Res Ctr GosNIIgenet, Moscow 113545, Russia

[2] Russian Acad Med Sci, Endocrinol Res Ctr, Moscow 117036, Russia

来源：

MOLECULAR BIOLOGY | 2000年 / 34卷 / 05期

关键词：

D11S2008; D11S907; C1167T; catalase gene; polymorphism; diabetes mellitus type 2; association;

D O I：

10.1007/BF02759615

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To study the contribution of the catalase (CAT) gene in diabetes mellitus (DM) type 2, the allele and genotype frequencies of internal (polymorphism C1167T) and two neighboring (minisatellites D11S907 and D11S2008) polymorphic markers were studied in 132 healthy individuals and 154 patients from Moscow. Allele C and genotype CC of the C1167T polymorphism proved associated with a higher risk of DM type 2. Seven D11S907 alleles containing 14 to 20 dinucleotide repeats were found. The frequencies of alleles 15 and 16 and genotype 18/20 were significantly higher and those of allele 18 and genotypes 17/18 and 18/19 were lower in patients than in controls. Eight D11S2008 alleles containing 15 to 22 tetranucleotide repeats were found. The frequencies of alleles 17 and 18 and genotype 18/20 in patients were significantly higher than in controls. An association of the three polymorphic loci and DM type 2 was suggested.

引用

页码：733 / 736

页数：4

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