Biocompatible metal-free organic phosphorescent nanoparticles for efficiently multidrug-resistant bacteria eradication

被引：32

作者：

Wang, Shan ^{[1
,2
]}

Xu, Miao ^{[1
,2
]}

Huang, Kaiwei ^{[1
,2
]}

Zhi, Jiahuan ^{[1
,2
]}

Sun, Chen ^{[1
,2
]}

Wang, Kai ^{[1
,2
]}

Zhou, Qian ^{[1
,2
]}

Gao, Lingling ^{[1
,2
]}

Jia, Qingyan ^{[3
,4
]}

Shi, Huifang ^{[1
,2
]}

An, Zhongfu ^{[1
,2
]}

Li, Peng ^{[1
,2
,3
,4
]}

Huang, Wei ^{[1
,2
,3
,4
]}

机构：

[1] Nanjing Tech Univ, NanjingTech, KLOFE, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanjing Tech Univ, NanjingTech, IAM, Nanjing 211816, Jiangsu, Peoples R China

[3] Northwestern Polytech Univ, Xian Inst Flexible Elect IFE, Xian 710072, Shaanxi, Peoples R China

[4] Northwestern Polytech Univ, IBME, Xian 710072, Shaanxi, Peoples R China

来源：

SCIENCE CHINA-MATERIALS | 2020年 / 63卷 / 02期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

organic phosphorescence; singlet oxygen; antimicrobial; photodynamic therapy; multidrug-resistant bacterium; ROOM-TEMPERATURE PHOSPHORESCENCE; ANTIBIOTICS; CANCER; BRIGHT;

D O I：

10.1007/s40843-019-1191-9

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Organic phosphorescence materials with longlived triplet excitons that can highly generate active singlet oxygen (O-1(2)) through the energy transfer with the molecular oxygen under photoexcitation, serve as highly efficient antibacterial agent. Herein, we report bright red-emissive organic phosphorescent nanoparticles (PNPs) based on a metal-free organic phosphor encapsulated with biocompatible block copolymers. The obtained PNPs with an ultra-small particle size of around 5 nm and a long emission lifetime of up to 167 mu s showed effective 1O2 generation ability under visible light (410 nm) excitation in aqueous media, which can efficiently eradicate multi-drug resistant bacteria both in vitro and in vivo. This is the first demonstration of metal-free organic PNPs for photodynamic antimicrobial therapy, expanding the application scope of metal-free organic room temperature phosphorescent materials.

引用

页码：316 / 324

页数：9

共 64 条

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