Modification of peptide by surface-wave plasma processing

被引：12

作者：

Motrescu, Iuliana ^{[1
,2
]}

Ogino, Akihisa ^{[1
]}

Tanaka, Shigeyasu ^{[1
]}

Fujiwara, Taketomo ^{[1
]}

Kodani, Shinya ^{[1
]}

Kawagishi, Hirokazu ^{[1
]}

Popa, Gheorghe ^{[2
]}

Nagatsu, Masaaki ^{[1
]}

机构：

[1] Shizuoka Univ, Grad Sch Sci & Technol, Naka Ku, Hamamatsu, Shizuoka 4328561, Japan

[2] Alexandru Ioan Cuza Univ, Fac Phys, Iasi 700506, Romania

来源：

THIN SOLID FILMS | 2010年 / 518卷 / 13期

基金：

日本学术振兴会;

关键词：

Plasma processing; Peptide; Protein; Modification; UV emission; LOW-TEMPERATURE PLASMAS; PRESSURE;

D O I：

10.1016/j.tsf.2009.11.029

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Fundamental research on the mechanisms of plasma-protein interactions is performed. The possibility of controlling the modification processes of peptides is investigated by changing gas species and treatment time. Changes of the peptide composition are analyzed by X-ray photoelectron spectroscopy using [Arg(8)]-Vasotocin as peptide, under different discharge conditions. The XPS results show that the modifications depend on the discharging gas (such as argon, oxygen and nitrogen). Ultraviolet radiation emitted by the plasma contributes to the alteration of disulfide (S-S) bond in [Arg(8)]-Vasotocin, which might be responsible for the loss of biological function. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：3585 / 3589

页数：5

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