Liposome containing cinnamon oil with antibacterial activity against methicillin-resistant Staphylococcus aureus biofilm

被引：148

作者：

Cui, Haiying ^{[1
]}

Li, Wei ^{[1
]}

Li, Changzhu ^{[2
]}

Vittayapadung, Saritporn ^{[3
]}

Lin, Lin ^{[1
]}

机构：

[1] Jiangsu Univ, Sch Food & Biol Engn, Zhenjiang, Peoples R China

[2] Hunan Acad Forestry, Dept Bioresource, Changsha, Hunan, Peoples R China

[3] Chiangrai Rajabhat Univ, Fac Sci & Technol, Chiangrai, Thailand

来源：

BIOFOULING | 2016年 / 32卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Liposome; cinnamon oil; MRSA; antibacterial activity; biofilms; ESCHERICHIA-COLI; PHYSICOCHEMICAL CHARACTERISTICS; FOOD; NANOLIPOSOMES; COMBINATION; GROWTH; ASSAY;

D O I：

10.1080/08927014.2015.1134516

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The global burden of bacterial disease remains high and is set against a backdrop of increasing antimicrobial resistance. There is a pressing need for highly effective and natural antibacterial agents. In this work, the anti-biofilm effect of cinnamon oil on methicillin-resistant Staphylococcus aureus was evaluated. Then, cinnamon oil was encapsulated in liposomes to enhance its chemical stability. The anti-biofilm activities of the liposome-encapsulated cinnamon oil against MRSA biofilms on stainless steel, gauze, nylon membrane and non-woven fabrics were evaluated by colony forming unit determination. Scanning electron microscopy and laser scanning confocal microscopy analyses were employed to observe the morphological changes in MRSA biofilms treated with the encapsulated cinnamon oil. As a natural and safe spice, the cinnamon oil exhibited a satisfactory antibacterial performance on MRSA and its biofilms. The application of liposomes further improves the stability of antimicrobial agents and extends the action time.

引用

页码：215 / 225

页数：11