The Role of Resveratrol in Eye Diseases-A Review of the Literature

被引：30

作者：

Bryl, Anna ^{[1
]}

Falkowski, Mariusz ^{[2
]}

Zorena, Katarzyna ^{[3
]}

Mrugacz, Malgorzata ^{[1
]}

机构：

[1] Med Univ Bialystok, Dept Ophthalmol & Eye Rehabil, PL-15089 Bialystok, Poland

[2] Med Univ Bialystok, PhD Studies, PL-15089 Bialystok, Poland

[3] Med Univ Gdansk, Dept Immunobiol & Environm Microbiol, PL-80211 Gdansk, Poland

来源：

NUTRIENTS | 2022年 / 14卷 / 14期

关键词：

resveratrol; molecular mechanisms; chronic eye diseases; FACTOR-KAPPA-B; PIGMENT EPITHELIAL-CELLS; OXIDATIVE STRESS; TRANS-RESVERATROL; RED WINE; ANTIOXIDANT PROPERTIES; INDUCED INFLAMMATION; DOWN-REGULATION; NITRIC-OXIDE; TUMOR-GROWTH;

D O I：

10.3390/nu14142974

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Resveratrol (3,5,4 '-trans-trihydroxystilbene) is a polyphenolic phytoalexin belonging to the stilbene family. It is commonly found in grape skins and seeds, as well as other plant-based foods. Oxidative stress and inflammation play a key role in the initiation and progression of age-related eye disorders (glaucoma, cataracts, diabetic retinopathy, and macular degeneration) that lead to a progressive loss of vision and blindness. Even though the way resveratrol affects the human body and the course of many diseases is still the subject of ongoing scientific research, it has been shown that the broad spectrum of anti-inflammatory and neuroprotective properties of resveratrol has a beneficial effect on eye tissues. In our research, we decided to analyze the current scientific literature on resveratrol, its possible mechanisms of action, and its therapeutic application in order to assess its effectiveness in eye diseases.

引用

页数：15

共 139 条

[1] Topical Quercetin and Resveratrol Protect the Ocular Surface in Experimental Dry Eye Disease [J].