High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential

被引：40
|
作者：
Wang, Lu [1 ]
Zhang, Ji [3 ]
Xia, Min [1 ,2 ]
Liu, Chang [4 ]
Zu, Xuyu [1 ,2 ]
Zhong, Jing [1 ,2 ]
机构：
[1] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Inst Clin Med, Hengyang 421001, Hunan, Peoples R China
[2] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Canc Res Inst, Hengyang 421001, Hunan, Peoples R China
[3] Shenzhen Tradit Chinese Med Hosp, Dept Clin Lab, Shenzhen 518033, Guangdong, Peoples R China
[4] Univ Southern Med, Peoples Hosp Chenzhou 1, Sch Clin Med 1, Dept Endocrinol & Metab, Guangzhou 510515, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2022年 / 18卷 / 11期
基金：
中国国家自然科学基金;
关键词：
High mobility group A1; Malignancies; Mechanisms; Chemoresistance; Targeting treatment; BREAST-CANCER CELLS; AT-HOOK; IN-VIVO; POSTTRANSLATIONAL MODIFICATIONS; HEPATOCELLULAR-CARCINOMA; INHIBITS PROLIFERATION; TARGETING HMGA1; GROUP PROTEINS; TUMOR-GROWTH; MASS-SPECTROMETRY;
D O I：
10.7150/ijbs.72952
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
High mobility group A1 (HMGA1) is a nonhistone chromatin structural protein characterized by no transcriptional activity. It mainly plays a regulatory role by modifying the structure of DNA. A large number of studies have confirmed that HMGA1 regulates genes related to tumours in the reproductive system, digestive system, urinary system and haematopoietic system. HMGA1 is rare in adult cells and increases in highly proliferative cells such as embryos. After being stimulated by external factors, it will produce effects through the Wnt/??-catenin, PI3K/Akt, Hippo and MEK/ERK pathways. In addition, HMGA1 also affects the ageing, apoptosis, autophagy and chemotherapy resistance of cancer cells, which are linked to tumorigenesis. In this review, we summarize the mechanisms of HMGA1 in cancer progression and discuss the potential clinical application of targeted HMGA1 therapy, indicating that targeted HMGA1 is of great significance in the diagnosis and treatment of malignancy.
引用
收藏
页码：4414 / 4431
页数：18
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