Modulation of matrix remodeling by SPARC in neoplastic progression

被引：119
作者：
Chlenski, Alexandre [1 ]
Cohn, Susan L. [1 ]
机构：
[1] Univ Chicago, Dept Pediat, Hematol Oncol Sect, Chicago, IL 60637 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 01期
关键词：
SPARC; Cancer; Tumor microenvironment; Matrix remodeling; FIBROBLAST-GROWTH-FACTOR; ENDOTHELIAL-CELL PROLIFERATION; MATRICELLULAR PROTEIN SPARC; CALCIUM-BINDING DOMAINS; INTEGRIN-LINKED KINASE; BREAST-CANCER CELLS; SECRETED PROTEIN; EXTRACELLULAR-MATRIX; CYSTEINE SPARC; NULL MICE;
D O I：
10.1016/j.semcdb.2009.11.018
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
SPARC is a matricellular glycoprotein that mediates interactions between cells and their microenvironment. It is produced at sites of tissue remodeling, where it regulates matrix deposition and turnover, cell adhesion, and signaling by extracellular factors, exerting profound effects on tissue architecture and cell physiology. During extensive matrix remodeling in neoplastic progression, SPARC is expressed in cancer-associated stroma and in malignant cells of some types, affecting tumor development, invasion, metastases, angiogenesis and inflammation. SPARC-induced changes in the tumor microenvironment can suppress or promote progression of different cancers depending on the tissue and cell type. Understanding the mechanism of matrix remodeling and its regulation by SPARC is essential for the development of new treatment strategies for highly aggressive cancers. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：55 / 65
页数：11
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