Modulation of matrix remodeling by SPARC in neoplastic progression

被引：119
作者：
Chlenski, Alexandre [1 ]
Cohn, Susan L. [1 ]
机构：
[1] Univ Chicago, Dept Pediat, Hematol Oncol Sect, Chicago, IL 60637 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 01期
关键词：
SPARC; Cancer; Tumor microenvironment; Matrix remodeling; FIBROBLAST-GROWTH-FACTOR; ENDOTHELIAL-CELL PROLIFERATION; MATRICELLULAR PROTEIN SPARC; CALCIUM-BINDING DOMAINS; INTEGRIN-LINKED KINASE; BREAST-CANCER CELLS; SECRETED PROTEIN; EXTRACELLULAR-MATRIX; CYSTEINE SPARC; NULL MICE;
D O I：
10.1016/j.semcdb.2009.11.018
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
SPARC is a matricellular glycoprotein that mediates interactions between cells and their microenvironment. It is produced at sites of tissue remodeling, where it regulates matrix deposition and turnover, cell adhesion, and signaling by extracellular factors, exerting profound effects on tissue architecture and cell physiology. During extensive matrix remodeling in neoplastic progression, SPARC is expressed in cancer-associated stroma and in malignant cells of some types, affecting tumor development, invasion, metastases, angiogenesis and inflammation. SPARC-induced changes in the tumor microenvironment can suppress or promote progression of different cancers depending on the tissue and cell type. Understanding the mechanism of matrix remodeling and its regulation by SPARC is essential for the development of new treatment strategies for highly aggressive cancers. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：55 / 65
页数：11
相关论文
共 146 条
  • [1] Matricellular proteins: Extracellular modulators of bone development, remodeling, and regeneration
    Alford, Andrea I.
    Hankenson, Kurt D.
    [J]. BONE, 2006, 38 (06) : 749 - 757
  • [2] Secreted protein acidic and rich in cysteine produced by human melanoma cells modulates polymorphonuclear leukocyte recruitment and antitumor cytotoxic capacity
    Alvarez, MJ
    Prada, F
    Salvatierra, E
    Bravo, AI
    Lutzky, VP
    Carbone, C
    Pitossi, FJ
    Chuluyan, HE
    Podhajcer, OL
    [J]. CANCER RESEARCH, 2005, 65 (12) : 5123 - 5132
  • [3] Forced expression of MMP9 rescues the, loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC
    Arnold, Shanna
    Mira, Emilia
    Muneer, Sabeeha
    Korpanty, Grzegorz
    Beck, Adam W.
    Holloway, Shane E.
    Manes, Santos
    Brekken, Rolf A.
    [J]. EXPERIMENTAL BIOLOGY AND MEDICINE, 2008, 233 (07) : 860 - 873
  • [4] SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity
    Barker, TH
    Baneyx, G
    Cardó-Vila, M
    Workman, GA
    Weaver, M
    Menon, PM
    Dedhar, S
    Rempel, SA
    Arap, W
    Pasqualini, R
    Vogel, V
    Sage, EH
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (43) : 36483 - 36493
  • [5] Stromal remodeling and SPARC (secreted protein acid rich in cysteine) expression in invasive ductal carcinomas of the breast
    Barth, PJ
    Moll, R
    Ramaswamy, A
    [J]. VIRCHOWS ARCHIV, 2005, 446 (05) : 532 - 536
  • [6] BELLAHCENE A, 1995, AM J PATHOL, V146, P95
  • [7] Proteolytic activity of human osteoclast cathepsin K - Expression, purification, activation, and substrate identification
    Bossard, MJ
    Tomaszek, TA
    Thompson, SK
    Amegadzie, BY
    Hanning, CR
    Jones, C
    Kurdyla, JT
    McNulty, DE
    Drake, FH
    Gowen, M
    Levy, MA
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (21) : 12517 - 12524
  • [8] SPARC-null mice display abnormalities in the dermis characterized by decreased collagen fibril diameter and reduced tensile strength
    Bradshaw, AD
    Puolakkainen, P
    Dasgupta, J
    Davidson, JM
    Wight, TN
    Sage, EH
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 120 (06) : 949 - 955
  • [9] SPARC-null mice exhibit increased adiposity without significant differences in overall body weight
    Bradshaw, AD
    Graves, DC
    Motamed, K
    Sage, EH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (10) : 6045 - 6050
  • [10] Bradshaw AD, 2002, J HISTOCHEM CYTOCHEM, V50, P1
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