Palladium-Catalyzed Cyclization of Free Hydroxyalkenoic Acids: Regio- and Chemoselective Access to Methylene Lactones

被引：2
作者：
Mostinski, Yelena [1 ]
Kotikalapudi, Ramesh [1 ]
Valerio, Viviana [1 ]
Nataf, Riva [1 ]
Tsvelikhovsky, Dmitry [1 ]
机构：
[1] Hebrew Univ Jerusalem, Inst Drug Res, Fac Med, IL-91120 Jerusalem, Israel
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 07期
关键词：
cyclizations; hydroxyalkenoic acids; lactones; palladium; regioselectivity; ALLYLIC ALKYLATIONS; HYDROAMINATION; DIENES; PHEROMONE; ADDITIONS; RINGS; WATER;
D O I：
10.1002/adsc.201601346
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A general and collective synthesis of medium-sized methylene lactones via controlled cyclizations of easily accessible collective precursors is described. The rapid composition of key-hydroxyalkenoic acid scaffold yields an assembly of oxocanones, oxepanones, and pyranones in a regioselective and stereodirected fashion via palladium-catalyzed cyclization.
引用
收藏
页码：1164 / 1169
页数：6
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