Variants in FAM13A are associated with chronic obstructive pulmonary disease

被引：308

作者：

Cho, Michael H. ^{[1
,2
]}

Boutaoui, Nadia ^{[1
]}

Klanderman, Barbara J. ^{[1
]}

Sylvia, Jody S. ^{[1
]}

Ziniti, John P. ^{[1
]}

Hersh, Craig P. ^{[1
,2
]}

DeMeo, Dawn L. ^{[1
,2
]}

Hunninghake, Gary M. ^{[1
,2
]}

Litonjua, Augusto A. ^{[1
,2
]}

Sparrow, David ^{[3
,4
,5
]}

Lange, Christoph ^{[6
]}

Won, Sungho ^{[6
]}

Murphy, James R. ^{[7
]}

Beaty, Terri H. ^{[8
]}

Regan, Elizabeth A. ^{[7
]}

Make, Barry J. ^{[7
]}

Hokanson, John E. ^{[9
]}

Crapo, James D. ^{[7
]}

Kong, Xiangyang ^{[10
]}

Anderson, Wayne H. ^{[11
]}

Tal-Singer, Ruth ^{[10
]}

Lomas, David A. ^{[12
]}

Bakke, Per ^{[13
,14
]}

Gulsvik, Amund ^{[13
,14
]}

Pillai, Sreekumar G. ^{[11
]}

Silverman, Edwin K. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Div Pulm & Crit Care Med, Dept Med, Boston, MA 02115 USA

[3] Vet Adm Boston Healthcare Syst, Boston, MA USA

[4] Boston Univ, Sch Publ Hlth, Boston, MA USA

[5] Boston Univ, Sch Med, Boston, MA 02118 USA

[6] Harvard Univ, Sch Publ Hlth, Boston, MA 02115 USA

[7] Natl Jewish Med & Res Ctr, Denver, CO USA

[8] Johns Hopkins Sch Publ Hlth, Baltimore, MD USA

[9] Univ Colorado Denver, Dept Epidemiol, Colorado Sch Publ Hlth, Aurora, CO USA

[10] GlaxoSmithKline Res & Dev Ltd, King Of Prussia, PA USA

[11] GlaxoSmithKline Res & Dev Ltd, Res Triangle Pk, NC USA

[12] Univ Cambridge, Cambridge Inst Med Res, Cambridge, England

[13] Haukeland Hosp, N-5021 Bergen, Norway

[14] Univ Bergen, Inst Med, Bergen, Norway

来源：

NATURE GENETICS | 2010年 / 42卷 / 03期

基金：

美国医疗保健研究与质量局; 美国国家卫生研究院;

关键词：

GENE-EXPRESSION;

D O I：

10.1038/ng.535

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83).

引用

页码：200 / 202

页数：3

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