Lipase-catalyzed enantioselective esterification of (S)-naproxen hydroxyalkyl ester in organic media

被引：25
|
作者：
Shang, CS [1 ]
Hsu, CS [1 ]
机构：
[1] So Taiwan Univ Technol, Dept Biotechnol, Tainan 710, Taiwan
来源：
BIOTECHNOLOGY LETTERS | 2003年 / 25卷 / 05期
关键词：
esterification; lipase; (S)-naproxen hydroxyalkyl ester;
D O I：
10.1023/A:1022948009889
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A lipase-catalyzed, enantioselective esterification process in organic solvents was developed for the synthesis of (S)-naproxen hydroxyalkyl ester. With the selection of lipase (Candida rugosa lipase) and reaction medium (isooctane and cyclohexane), a high enantiomeric ratio of > 100 for the enzyme was obtained. 1,4-Butanediol was the best acyl acceptor. The carbon chain length of the alcohol had a major effect on the enzyme activity and enantioselectivity of lipase-catalyzed esterification.
引用
收藏
页码：413 / 416
页数：4
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