Direct C3 Carbamoylation of 2H-Indazoles

被引：18

作者：

Bhat, Vighneshwar Shridhar ^{[1
]}

Lee, Anna ^{[1
]}

机构：

[1] Jeonbuk Natl Univ, Dept Chem, Jeonju 54896, South Korea

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 2021卷 / 23期

基金：

新加坡国家研究基金会;

关键词：

Carbamoylation; 2H-Indazoles; Minisci reaction; Radical reaction; Synthetic methods; PHOTOREDOX CATALYSIS; INDAZOLES; FUNCTIONALIZATION; DERIVATIVES; INHIBITORS; RADICALS; DESIGN; LIGHT;

D O I：

10.1002/ejoc.202100461

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We developed a novel method for direct C3 carbamoylation of 2H-indazoles using oxamic acids as carbamoyl radical sources. In the presence of ammonium persulfate, carbamoyl radicals were generated from oxamic acids, then used for further reactions with 2H-indazoles to afford the desired products. The reaction proceeds under metal- and catalyst-free conditions. This simple process allows for the efficient synthesis of C3 carbamoylated 2H-indazoles, which are important scaffolds in organic synthesis.

引用

页码：3382 / 3385

页数：4

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