Functions of Coronavirus Accessory Proteins: Overview of the State of the Art

被引：33
作者：
Fang, Puxian [1 ,2 ]
Fang, Liurong [1 ,2 ]
Zhang, Huichang [1 ,2 ]
Xia, Sijin [1 ,2 ]
Xiao, Shaobo [1 ,2 ,3 ]
机构：
[1] Huazhong Agr Univ, Coll Vet Med, State Key Lab Agr Microbiol, Wuhan 430070, Peoples R China
[2] Cooperat Innovat Ctr Sustainable Pig Prod, Key Lab Prevent Vet Med Hubei Prov, Wuhan 430070, Peoples R China
[3] Huazhong Agr Univ, Coll Vet Med, Lab Anim Virol, Wuhan 430070, Peoples R China
来源：
VIRUSES-BASEL | 2021年 / 13卷 / 06期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
coronavirus; accessory protein; innate immunity; infection; pathogenesis; RESPIRATORY SYNDROME CORONAVIRUS; ENDOPLASMIC-RETICULUM STRESS; INFECTIOUS PERITONITIS VIRUS; I-LIKE RECEPTORS; NF-KAPPA-B; PORCINE DELTACORONAVIRUS PDCOV; ION-CHANNEL; RIG-I; SARS-COV; C VIRUS;
D O I：
10.3390/v13061139
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Coronavirus accessory proteins are a unique set of proteins whose genes are interspersed among or within the genes encoding structural proteins. Different coronavirus genera, or even different species within the same coronavirus genus, encode varying amounts of accessory proteins, leading to genus- or species-specificity. Though accessory proteins are dispensable for the replication of coronavirus in vitro, they play important roles in regulating innate immunity, viral proliferation, and pathogenicity. The function of accessory proteins on virus infection and pathogenesis is an area of particular interest. In this review, we summarize the current knowledge on accessory proteins of several representative coronaviruses that infect humans or animals, including the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with an emphasis on their roles in interaction between virus and host, mainly involving stress response, innate immunity, autophagy, and apoptosis. The cross-talking among these pathways is also discussed.
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页数：21
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