Stepwise solid-phase synthesis of peptide-oligonucleotide phosphorothioate conjugates employing Fmoc peptide chemistry

被引：27

作者：

Antopolsky, M ^{[1
]}

Azhayev, A ^{[1
]}

机构：

[1] Univ Kuopio, Dept Pharmaceut Chem, FIN-70211 Kuopio, Finland

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 47期

关键词：

D O I：

10.1016/S0040-4039(00)01627-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward stepwise method for the preparation of peptide-oligonucleotide phosphorothioate conjugates, was developed, based on the highly efficient Fmoc peptide solid phase synthesis, followed by oligonucleotide phosphorothiate chain assembly. The three conjugates synthesized contained 15- or 17-mer oligonucleotide phosphorothioates and 10- or 16-mer peptides, incorporating two or three arginine residues. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9113 / 9117

页数：5

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