Amidines for Versatile Cobalt(III)-Catalyzed Synthesis of Isoquinolines through C-H Functionalization with Diazo Compounds

被引：148

作者：

Li, Jie ^{[1
]}

Tang, Mengyao ^{[1
]}

Zang, Lei ^{[1
]}

Zhang, Xiaolei ^{[1
]}

Zhang, Zhao ^{[1
]}

Ackermann, Lutz ^{[2
]}

机构：

[1] Jiangnan Univ, Sch Pharmaceut Sci, Lihu Rd 1800, Wuxi 214122, Peoples R China

[2] Univ Gottingen, Inst Organ & Biomol Chem, Tammannstr 2, D-37077 Gottingen, Germany

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 11期

基金：

欧洲研究理事会;

关键词：

N-TYPE REACTIONS; DIRECTED FUNCTIONALIZATION; UNPROTECTED INDOLES; SELECTIVE ACCESS; BOND ACTIVATION; AMIDATION; ARENES; CYANATION; ALKYNES; ALKENYLATIONS;

D O I：

10.1021/acs.orglett.6b01199

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A cobalt(III),-catalyzed C-H/N-H bond functionalization for the synthesis of 1-aniinoisoquincilines from aryl amidines and diazo compounds has been developed: The reaction proceeds under mild reaction conditions, obviates the need for oxidants, produces only N-2 and H2O as the byproducts, and features a broad substrate scope.

引用

页码：2742 / 2745

页数：4

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