Rapid and efficient synthesis of 2-Amino-4H-benzothiazines

被引：50

作者：

Hari, A ^{[1
]}

Miller, BL ^{[1
]}

机构：

[1] Univ Rochester, Dept Chem, Rochester, NY 14627 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 23期

关键词：

D O I：

10.1021/ol006580m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The benzothiazine nucleus is a relatively unexplored class of compounds, from the standpoint of both synthetic chemistry and biological activity. We have developed a rapid, high yielding synthesis of benzothiazines in which a precursor aryl thiourea is prepared on solid phase, Addition of trifluoroacetic acid catalyzes a conjugate addition reaction to form the desired heterocycle and releases it from the resin.

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页码：3667 / 3670

页数：4

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