Lung Injury Induced by TiO2 Nanoparticles Depends on Their Structural Features: Size, Shape, Crystal Phases, and Surface Coating

被引:103
作者
Wang, Jiangxue [1 ]
Fan, Yubo [1 ]
机构
[1] Beihang Univ, Sch Biol Sci & Med Engn, Minist Educ, Key Lab Biomech & Mechanobiol, Beijing 100191, Peoples R China
基金
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词
TiO2; nanoparticles; nanotoxicology; physicochemical property; lung injury; pulmonary inflammation; TITANIUM-DIOXIDE NANOPARTICLES; IN-VITRO CYTOTOXICITY; NANO GO CONSORTIUM; INFLAMMATORY RESPONSE; PULMONARY RESPONSES; ULTRAFINE PARTICLES; ENGINEERED NANOMATERIALS; OXIDATIVE STRESS; EPITHELIAL-CELLS; A549; CELLS;
D O I
10.3390/ijms151222258
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
With the rapid development of nanotechnology, a variety of engineered nanoparticles (NPs) are being produced. Nanotoxicology has become a hot topic in many fields, as researchers attempt to elucidate the potential adverse health effects of NPs. The biological activity of NPs strongly depends on physicochemical parameters but these are not routinely considered in toxicity screening, such as dose metrics. In this work, nanoscale titanium dioxide (TiO2), one of the most commonly produced and widely used NPs, is put forth as a representative. The correlation between the lung toxicity and pulmonary cell impairment related to TiO2 NPs and its unusual structural features, including size, shape, crystal phases, and surface coating, is reviewed in detail. The reactive oxygen species (ROS) production in pulmonary inflammation in response to the properties of TiO2 NPs is also briefly described. To fully understand the potential biological effects of NPs in toxicity screening, we highly recommend that the size, crystal phase, dispersion and agglomeration status, surface coating, and chemical composition should be most appropriately characterized.
引用
收藏
页码:22258 / 22278
页数:21
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