Evaluation of structure-activity relationships of ginsenosides against amyloid β induced pathological behaviours in transgenic Caenorhabditis elegans

被引：8

作者：

Zhang, Mu ^{[1
]}

Qian, Fei ^{[1
]}

Liu, Qingling ^{[1
]}

Qian, Cheng ^{[1
]}

Thu, Pyone Myat ^{[1
]}

Wang, Yanyan ^{[1
]}

Zheng, Zu-Guo ^{[1
]}

Yang, Hua ^{[1
]}

Li, Ping ^{[1
]}

Xu, Xiaojun ^{[1
]}

机构：

[1] China Pharmaceut Univ, State Key Lab Nat Med, 24 Tongjia Lane, Nanjing 210009, Jiangsu, Peoples R China

来源：

RSC ADVANCES | 2017年 / 7卷 / 64期

基金：

中国国家自然科学基金;

关键词：

PROTOPANAXADIOL-TYPE SAPONINS; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; GINSENG SAPONINS; (A-BETA(1-42))-INDUCED PARALYSIS; SIGNALING PATHWAY; PRECURSOR PROTEIN; INDUCED TOXICITY; C-ELEGANS; MODEL;

D O I：

10.1039/c7ra05717b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Amyloid beta (A beta) induced toxicity has been postulated to initiate synaptic loss and subsequent neuronal degeneration in Alzheimer's disease (AD). The activities of ginsenosides against AD are widely reported, however, a systematic in vivo study comparing the effects of different ginsenosides on Ab induced toxicity and cognitive impairment has not been described. In addition, the correlation between molecular structures and their anti-A beta activities remains uncovered. In the present study, the in vivo anti-Ab effects of 17 ginsenosides were explored using three transgenic Caenorhabditis elegans (C. elegans) models that exhibits pathological behaviors associated with A beta. We found that (1) ginsenoside Rc, Rd, 20(S)-Rg3, Compound K (CK) and Rg1 could significantly reduce Ab deposits, (2) ginsenoside Rc, Rd, CK, Rk3 and Rg1 inhibit A beta induced paralysis, and (3) ginsenosides 20(S)-Rg3, CK and Rk3 prevented A beta induced defects in associative learning capacity and showed antioxidative activity both in vitro and in vivo. The structure-activity relationships of 17 ginsenosides were investigated by comparing their anti-A beta effects in C. elegans models. Results showed that the protopanaxadiol-type has higher activities than the protopanaxatriol-type or oleanane-type; the anti-A beta effects of ginsenosides are inversely related to the sugar numbers. The results of the present study gain insight into the in vivo protective effects of ginsenosides against A beta induced toxicity, and provide useful information for the clinical use of ginsenosides.

引用

页码：40095 / 40104

页数：10

共 77 条

[1] Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan [J].