Enhanced mechanical and biological performances of CaO-MgO-SiO2 glass-ceramics via the modulation of glass and ceramic phases

被引：20

作者：

Feng, Kuei-Chih ^{[1
,3
]}

Wu, Yu-Jie ^{[2
]}

Wang, Chi-Yun ^{[2
]}

Tu, Chi-Shun ^{[1
,2
,4
]}

Lin, Yu-Ling ^{[5
]}

Chen, Cheng-Sao ^{[6
]}

Lai, Po-Liang ^{[7
]}

Huang, Yu-Tzu ^{[5
]}

Chen, Pin-Yi ^{[1
,2
,3
]}

机构：

[1] Ming Chi Univ Technol, Res Ctr Intelligent Med Devices, New Taipei 24301, Taiwan

[2] Ming Chi Univ Technol, Int PhD Program Innovat Technol Biomed Engn & Med, New Taipei 24301, Taiwan

[3] Ming Chi Univ Technol, Dept Mech Engn, New Taipei 24301, Taiwan

[4] Fu Jen Catholic Univ, Dept Phys, New Taipei 24205, Taiwan

[5] Fu Jen Catholic Univ, Sch Med, New Taipei 24205, Taiwan

[6] Hwa Hsia Univ Technol, Dept Mech Engn, New Taipei 23567, Taiwan

[7] Chang Gung Mem Hosp, Bone & Joint Res Ctr, Taoyuan 33305, Taiwan

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2021年 / 124卷

关键词：

Mechanical strength; Biocompatibility; IN-VITRO BIOACTIVITY; DIOPSIDE CAMGSI2O6; CAO-MGO-AL2O3-SIO2; GLASS; DIELECTRIC-PROPERTIES; OSTEOGENIC DIFFERENTIATION; MAGNESIUM ALLOY; BONE; CRYSTALLIZATION; PROLIFERATION; DENSIFICATION;

D O I：

10.1016/j.msec.2021.112060

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

This work reports a new CaO-MgO-SiO2 (CMS) bioactive glass-ceramic, using ZrO2 as a nucleus to modulate the ratios of glass and ceramic phases as a function of sintering temperature. Mg-rich bioactive CMS glass-ceramics exhibit advantages regarding mechanical strength (flexural strength -190 MPa and compressive strength -555 MPa), in-vitro and in-vivo biocompatibilities, and bone ingrowth. The high mechanical strengths could be attributed to the CaMgSi2O6 glass-ceramic and lower porosity. X-ray absorption spectra indicate an increased Si?O covalent bond via the development of CaMgSi2O6 glass-ceramics. From the in-vitro cytotoxicity and BMSC differentiation assays, the CMS samples sintered above 800 ?C exhibited better cell attachment and differentiation, possibly due to structural stability, appropriate pore, and ion release to boost osteogenesis. Compared to hydroxyapatite (HA) ceramics, the CMS glass-ceramics display higher mechanical strengths, biocompatibility, and osteoconductivity. An in-vivo experiment demonstrated a fine bone-ingrowth profile around the CMS implant. This study may further the application of CMS glass-ceramics in bone implants.

引用

页数：12

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