Microbicide Dosage Forms

被引：19

作者：

Rohan, L. C. ^{[1
]}

Devlin, B. ^{[2
]}

Yang, H. ^{[1
]}

机构：

[1] Univ Pittsburgh, Sch Pharm, Dept Pharmaceut Sci, Magee Womens Res Inst, Pittsburgh, PA 15261 USA

[2] Int Partnership Microbicides, Silver Spring, MD USA

来源：

MICROBICIDES FOR PREVENTION OF HIV INFECTION | 2014年 / 383卷

关键词：

IMMUNODEFICIENCY-VIRUS TYPE-1; CONTRACEPTIVE VAGINAL RING; TISSUE-ENGINEERING SCAFFOLDS; CELLULOSE-ACETATE PHTHALATE; HIV-UNINFECTED WOMEN; IN-VITRO EVALUATION; CONTROLLED-RELEASE; NANOFIBROUS SCAFFOLDS; DRUG-DELIVERY; TOPICAL MICROBICIDES;

D O I：

10.1007/82_2013_357

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Microbicides are topically applied, user controlled dosage forms that are being developed to prevent the transmission of HIV during coitus. Early candidates focused on coitally dependent dosage forms such as gels and creams. More recent development has focused on broadening the coitally dependent options through the introduction of films and fast dissolving tablets. Additionally, it has become important to have longer acting products to minimize the burden of user compliance and thus vaginal rings have been developed providing sustained delivery of antiretroviral drugs. This chapter discusses the history of microbicides along with a detailed description of coitally dependent products, gels, films, tablets diaphragms, as well as coitally independent dosage forms such as vaginal rings and the introduction of a new technology, electrospun fibers.

引用

页码：27 / 54

页数：28

共 157 条

[1] Mucosal irritation potential of personal lubricants relates to product osmolality as detected by the slug mucosal irritation assay [J].

Adriaens, Els ;

Remon, Jean Paul .

SEXUALLY TRANSMITTED DISEASES, 2008, 35 (05) :512-516

[2] Formulation and Delivery of Microbicides [J].

Agashe, Hrushikesh ;

Hu, Minlu ;

Rohan, Lisa .

CURRENT HIV RESEARCH, 2012, 10 (01) :88-96

[3] Development and characterization of a vaginal film containing dapivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI), for prevention of HIV-1 sexual transmission [J].

Akil, Ayman ;

Parniak, Michael A. ;

Dezzutti, Charlene S. ;

Moncla, Bernard J. ;

Cost, Marilyn R. ;

Li, Mingguang ;

Rohan, Lisa Cencia .

DRUG DELIVERY AND TRANSLATIONAL RESEARCH, 2011, 1 (03) :209-222

[4] Why consider vaginal drug administration? [J].

Alexander, NJ ;

Baker, E ;

Kaptein, M ;

Karck, U ;

Miller, L ;

Zampaglione, E .

FERTILITY AND STERILITY, 2004, 82 (01) :1-12

[5]

[Anonymous], 2003, AAPS PHARMSCITECH

[6]

[Anonymous], CURR TOP MICROBIOL I

[7]

Austin GD, 1998, US patent Number, Patent No. [5, 900, 5900]

[8] Modulation of anisotropy in electrospun tissue-engineering scaffolds: Analysis of fiber alignment by the fast Fourier transform [J].

Ayres, Chantal ;

Bowlin, Gary L. ;

Henderson, Scott C. ;

Taylor, Leander ;

Shultz, Jackie ;

Alexander, John ;

Telemeco, Todd A. ;

Simpson, David G. .

BIOMATERIALS, 2006, 27 (32) :5524-5534

[9] Optimised Anaesthesia to Reduce Post Operative Cognitive Decline (POCD) in Older Patients Undergoing Elective Surgery, a Randomised Controlled Trial [J].

Ballard, Clive ;

Jones, Emma ;

Gauge, Nathan ;

Aarsland, Dag ;

Nilsen, Odd Bjarte ;

Saxby, Brian K. ;

Lowery, David ;

Corbett, Anne ;

Wesnes, Keith ;

Katsaiti, Eirini ;

Arden, James ;

Amaoko, Derek ;

Prophet, Nicholas ;

Purushothaman, Balaji ;

Green, David .

PLOS ONE, 2012, 7 (06)

[10] In Vitro Evaluation of Mucoadhesive Vaginal Tablets of Antifungal Drugs Prepared with Thiolated Polymer and Development of a New Dissolution Technique for Vaginal Formulations [J].

Baloglu, Esra ;

Senyigit, Zeynep Ay ;

Karavana, Sinem Yaprak ;

Vetter, Anja ;

Metin, Dilek Yesim ;

Polat, Suleyha Hilmioglu ;

Guneri, Tamer ;

Bernkop-Schnurch, Andreas .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (08) :952-958

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