Carnitine congener mildronate protects against stress-and haloperidol-induced impairment in memory and brain protein expression in rats

被引：5

作者：

Beitnere, Ulrika ^{[1
]}

Dzirkale, Zane ^{[1
]}

Isajevs, Sergejs ^{[2
,3
]}

Rumaks, Juris ^{[1
]}

Svirskis, Simons ^{[1
]}

Klusa, Vija ^{[1
]}

机构：

[1] Univ Latvia, Fac Med, Dept Pharmacol, LV-1586 Riga, Latvia

[2] Univ Latvia, Fac Med, Dept Pathol, LV-1586 Riga, Latvia

[3] Riga East Univ Hosp, Ctr Pathol, LV-1038 Riga, Latvia

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2014年 / 745卷

关键词：

Stress; Haloperidol; Memory; Protein expression; Mildronate; MESSENGER-RNA EXPRESSION; ALZHEIMERS-DISEASE; IMMOBILIZATION STRESS; NEUROTROPHIC FACTOR; NEUROPROTECTIVE PROPERTIES; WORKING-MEMORY; BDNF; HIPPOCAMPUS; ANTIPSYCHOTICS; MITOCHONDRIA;

D O I：

10.1016/j.ejphar.2014.10.014

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The present study investigates the efficacy of mildronate, a carnitine congener, to protect stress and haloperidol-induced impairment of memory in rats and the expression of brain protein biomarkers involved in synaptic plasticity, such as brain derived neurotrophic factor (BDNF), acetylcholine esterase and glutamate decarboxylase 67 (GAD67). Two amnesia models were used: 2 h immobilization stress and 3-week haloperidol treatment. Stress caused memory impairment in the passive avoidance test and induced a significant 2-fold BDNF elevation in hippocampal and striatal tissues that was completely inhibited by mildronate. MilcIronaLe decreased the level of GAD67 (but not acetylcholine esterase) expression by stress. Haloperidol decrease by a third hippocampal BDNF and acetylcholine esterase (but not GAD67) expression, which was normalized by mildronate; it also reversed the halopericlol-induced memory impairment in Barnes Lest. The results suggest the usefulness of mildronate as protector against neuronal disturbances caused by stress or halopericlol. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：76 / 83

页数：8

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