Neuroscience of fear extinction: Implications for assessment and treatment of fear-based and anxiety related disorders

被引：114

作者：

Milad, Mohammed R. ^{[1
]}

Rosenbaum, Blake L. ^{[1
]}

Simon, Naomi M. ^{[2
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Dept Psychiat, Sch Med, Charlestown, MA 02129 USA

[2] Harvard Univ, Massachusetts Gen Hosp, Dept Psychiat, Ctr Anxiety & Traumat Stress Disorders,Med Sch, Boston, MA 02114 USA

来源：

BEHAVIOUR RESEARCH AND THERAPY | 2014年 / 62卷

关键词：

Fear conditioning; vmPFC; Amygdala; Exposure therapy; Yohimbine; DCS; POSTTRAUMATIC-STRESS-DISORDER; MEDIAL PREFRONTAL CORTEX; COGNITIVE-BEHAVIORAL THERAPY; ANTERIOR CINGULATE CORTEX; D-CYCLOSERINE ENHANCEMENT; PLACEBO-CONTROLLED TRIAL; EXPOSURE THERAPY; CONDITIONED FEAR; TREATMENT RESPONSE; PREDICTS RESPONSE;

D O I：

10.1016/j.brat.2014.08.006

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

Current exposure-based therapies aimed to reduce pathological fear and anxiety are now amongst the most effective interventions for trauma and anxiety related disorders. Nevertheless, they can be further improved to enhance initial and long-term outcomes. It is now widely accepted that a greater understanding of the neurobiological mechanisms of fear extinction is needed to further develop and identify novel effective targeted treatments as well as prevention strategies for fear-based and anxiety-related disorders. Guided by elegant mechanistic, cellular, and molecular preclinical reports, data from imaging studies are beginning to shape our understanding of how fear is quelled in the human brain. In this article, we briefly review the neural circuits underlying fear extinction in rodents and healthy humans. We then review how these circuits may fail to extinguish fear in patients with anxiety disorders. We end with a discussion examining how fear extinction research may lead to significant advances of current therapeutics for anxiety disorders. (C) 2014 Elsevier Ltd. All rights reserved.U

引用

页码：17 / 23

页数：7

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