Central Nervous System Relapse After Stem Cell Transplantation in Adolescents and Young Adults with Acute Lymphoblastic Leukemia: A Single-Institution Experience
被引:8
作者:
Kozak, Margaret M.
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机构:
Stanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USAStanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USA
Kozak, Margaret M.
[1
]
Yoo, Christopher H.
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机构:
Stanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USAStanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USA
Yoo, Christopher H.
[1
]
Gutkin, Paulina M.
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机构:
Stanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USAStanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USA
Gutkin, Paulina M.
[1
]
von Eyben, Rie
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h-index: 0
机构:
Stanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USAStanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USA
von Eyben, Rie
[1
]
Agarwal, Rajni
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机构:
Stanford Univ, Dept Pediat, Div Stem Cell Transplantat & Regenerat Med, Stanford, CA 94305 USAStanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USA
Agarwal, Rajni
[2
]
Donaldson, Sarah S.
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h-index: 0
机构:
Stanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USAStanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USA
Donaldson, Sarah S.
[1
]
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Muffly, Lori
[3
]
Hiniker, Susan M.
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h-index: 0
机构:
Stanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USAStanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USA
Hiniker, Susan M.
[1
]
机构:
[1] Stanford Canc Inst, Dept Radiat Oncol, 875 Blake Wilbur Dr, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Pediat, Div Stem Cell Transplantat & Regenerat Med, Stanford, CA 94305 USA
[3] Stanford Univ, Dept Med, Div Blood & Bone Marrow Transplantat, Stanford, CA 94305 USA
Purpose: To evaluate outcomes and central nervous system (CNS) relapse in adolescents and young adults (AYAs) with acute lymphoblastic leukemia (ALL), who underwent total body irradiation (TBI) before allogeneic hematopoietic stem cell transplantation (allo-SCT). Methods: A total of 136 AYA patients with ALL who received TBI before allo-SCT between 1998 and 2018 were reviewed. Twenty patients received cranial radiation in their initial treatment before conditioning for transplant and were excluded. Competing risk analysis was used to estimate the cumulative incidence of relapse. Kaplan-Meier and log-rank tests were used to calculate overall survival (OS) and to identify factors predictive of relapse. OS and time to relapse were calculated from date of allo-SCT. Results: One hundred sixteen patients were included in the analysis. Median age was 27 years and median follow-up time was 42 months. Twenty-six patients suffered a disease relapse and 49 died, 26 of posttransplantation complications. The median time to relapse was 7 months and the 5-year OS was 60%. Seven patients had a CNS relapse: 4 of 20 patients (25%) with pre-SCT CNS disease had a post-allo-SCT CNS relapse compared to 3 of 97 (3.1%) without pre-SCT CNS disease. Median time to CNS relapse was 7 months. Patients with post-SCT CNS relapse had median OS of 19 months. Conclusions: AYA patients with CNS disease who undergo an allo-SCT have a high rate of CNS relapse. The addition of additional CNS-directed therapy to transplant protocols warrants further investigation.
机构:
Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Tokyo Metropolitan Otsuka Hosp, Dept Hematol, Tokyo, Japan
Kanagawa Canc Ctr, Dept Hematol, Yokohama, Kanagawa 2418515, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Aoki, Jun
Ishiyama, Ken
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机构:
Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Tokyo Metropolitan Otsuka Hosp, Dept Hematol, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Ishiyama, Ken
Taniguchi, Shuichi
论文数: 0引用数: 0
h-index: 0
机构:
Toranomon Gen Hosp, Dept Hematol, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Taniguchi, Shuichi
Fukuda, Takahiro
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Fukuda, Takahiro
Ohashi, Kazuteru
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Ohashi, Kazuteru
Ogawa, Hiroyasu
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h-index: 0
机构:
Hyogo Coll Med, Dept Internal Med, Div Hematol, Kobe, Hyogo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
机构:
Hamanoumachi Hosp, Dept Hematol, Fukuoka, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Eto, Tetsuya
Iwato, Koji
论文数: 0引用数: 0
h-index: 0
机构:
Hiroshima Red Cross Hosp, Dept Hematol, Hiroshima, Japan
Atom Bomb Survivors Hosp, Hiroshima, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Iwato, Koji
Sakamaki, Hisashi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Sakamaki, Hisashi
Morishima, Yasuo
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h-index: 0
机构:
Aichi Canc Ctr Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Morishima, Yasuo
Nagamura, Tokiko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Dept Cell Proc & Transfus, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Nagamura, Tokiko
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机构:
Atsuta, Yoshiko
Takami, Akiyoshi
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Nagoya, Aichi, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
机构:
Univ Tehran Med Sci, Sch Med, Dept Pediat, Pediat Hematol & Oncol Program, Tehran, Iran
Univ Tehran Med Sci, Pediat Cell & Gene Therapy Res Ctr, Gene Cell & Tissue Res Inst, Tehran, IranUniv Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
Enshaei, Mercedeh
Monzavi, Seyed Mostafa
论文数: 0引用数: 0
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机构:
Univ Tehran Med Sci, Sch Adv Technol Med, Dept Appl Cell Sci, Tehran, IranUniv Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
Monzavi, Seyed Mostafa
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Kabootari, Maryam
Behfar, Maryam
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Pediat Cell & Gene Therapy Res Ctr, Gene Cell & Tissue Res Inst, Tehran, Iran
Univ Tehran Med Sci, Childrens Med Ctr, Dept Pediat Stem Cell Transplantat, Tehran, IranUniv Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
Behfar, Maryam
Hamidieh, Amir Ali
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Pediat Cell & Gene Therapy Res Ctr, Gene Cell & Tissue Res Inst, Tehran, Iran
Univ Tehran Med Sci, Childrens Med Ctr, Dept Pediat Stem Cell Transplantat, Tehran, IranUniv Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Zhang, Li-Dan
Li, Yan-Hong
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机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Li, Yan-Hong
Ke, Zhi-Yong
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h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Ke, Zhi-Yong
Huang, Li-Bin
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h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Huang, Li-Bin
Luo, Xue-Qun
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h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
机构:
Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Tokyo Metropolitan Otsuka Hosp, Dept Hematol, Tokyo, Japan
Kanagawa Canc Ctr, Dept Hematol, Yokohama, Kanagawa 2418515, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Aoki, Jun
Ishiyama, Ken
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Tokyo Metropolitan Otsuka Hosp, Dept Hematol, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Ishiyama, Ken
Taniguchi, Shuichi
论文数: 0引用数: 0
h-index: 0
机构:
Toranomon Gen Hosp, Dept Hematol, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Taniguchi, Shuichi
Fukuda, Takahiro
论文数: 0引用数: 0
h-index: 0
机构:
Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Fukuda, Takahiro
Ohashi, Kazuteru
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Ohashi, Kazuteru
Ogawa, Hiroyasu
论文数: 0引用数: 0
h-index: 0
机构:
Hyogo Coll Med, Dept Internal Med, Div Hematol, Kobe, Hyogo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
机构:
Hamanoumachi Hosp, Dept Hematol, Fukuoka, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Eto, Tetsuya
Iwato, Koji
论文数: 0引用数: 0
h-index: 0
机构:
Hiroshima Red Cross Hosp, Dept Hematol, Hiroshima, Japan
Atom Bomb Survivors Hosp, Hiroshima, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Iwato, Koji
Sakamaki, Hisashi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Sakamaki, Hisashi
Morishima, Yasuo
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Canc Ctr Res Inst, Div Epidemiol & Prevent, Nagoya, Aichi, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Morishima, Yasuo
Nagamura, Tokiko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Med Sci, Dept Cell Proc & Transfus, Tokyo, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
Nagamura, Tokiko
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机构:
Atsuta, Yoshiko
Takami, Akiyoshi
论文数: 0引用数: 0
h-index: 0
机构:
Aichi Med Univ, Dept Internal Med, Div Hematol, Nagoya, Aichi, JapanTokyo Metropolitan Canc & Infect Dis Ctr, Komagome Hosp, Dept Hematol, Tokyo, Japan
机构:
Univ Tehran Med Sci, Sch Med, Dept Pediat, Pediat Hematol & Oncol Program, Tehran, Iran
Univ Tehran Med Sci, Pediat Cell & Gene Therapy Res Ctr, Gene Cell & Tissue Res Inst, Tehran, IranUniv Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
Enshaei, Mercedeh
Monzavi, Seyed Mostafa
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Sch Adv Technol Med, Dept Appl Cell Sci, Tehran, IranUniv Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
Monzavi, Seyed Mostafa
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机构:
Kabootari, Maryam
Behfar, Maryam
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Pediat Cell & Gene Therapy Res Ctr, Gene Cell & Tissue Res Inst, Tehran, Iran
Univ Tehran Med Sci, Childrens Med Ctr, Dept Pediat Stem Cell Transplantat, Tehran, IranUniv Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
Behfar, Maryam
Hamidieh, Amir Ali
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tehran Med Sci, Pediat Cell & Gene Therapy Res Ctr, Gene Cell & Tissue Res Inst, Tehran, Iran
Univ Tehran Med Sci, Childrens Med Ctr, Dept Pediat Stem Cell Transplantat, Tehran, IranUniv Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Zhang, Li-Dan
Li, Yan-Hong
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Li, Yan-Hong
Ke, Zhi-Yong
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Ke, Zhi-Yong
Huang, Li-Bin
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China
Huang, Li-Bin
Luo, Xue-Qun
论文数: 0引用数: 0
h-index: 0
机构:
Sun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R ChinaSun Yat Sen Univ, Affiliated Hosp 1, Dept Paediat, Guangzhou 510080, Guangdong, Peoples R China