Transition-Metal-Free N-O Reduction of Oximes: A Modular Synthesis of Fluorinated Pyridines

被引：67
作者：
Huang, Huawen [1 ]
Cai, Jinhui [1 ]
Xie, Hao [1 ]
Tan, Jing [1 ]
Li, Feifei [1 ]
Deng, Guo-Jun [1 ]
机构：
[1] Xiangtan Univ, Coll Chem, Minist Educ, Key Lab Environm Friendly Chem & Applicat, Xiangtan 411105, Peoples R China
来源：
ORGANIC LETTERS | 2017年 / 19卷 / 14期
基金：
中国国家自然科学基金;
关键词：
C-H; CATALYZED CYCLIZATION; MEDICINAL CHEMISTRY; COUPLING REACTIONS; ACYL OXIMES; PROGRESS; ACETATES; STRATEGY; INDOLES; CASCADE;
D O I：
10.1021/acs.orglett.7b01564
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An NH4I-based reductive system has been explored to promote :the oxime N-O bond cleavage and thereby enable a Modular synthesis of a broad range, of pharmacologically significant fluorinated pyridines. Compared With traditional condensation methods for pyridine assembly, this protocol was found to be highly regio- and chemoselective and presented broad functional group tolerance.
引用
收藏
页码：3743 / 3746
页数：4
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