High Expression of the Newly Found Long Noncoding RNA Z38 Promotes Cell Proliferation and Oncogenic Activity in Breast Cancer

被引：37

作者：

Deng, Rilin ^{[1
]}

Liu, Bin ^{[1
]}

Wang, Yan ^{[2
]}

Yan, Feng ^{[3
]}

Hu, Shifan ^{[1
]}

Wang, Hongcan ^{[1
]}

Wang, Tingting ^{[1
]}

Li, Bin ^{[1
]}

Deng, Xiyun ^{[4
]}

Xiang, Shuanglin ^{[3
]}

Yang, Yinke ^{[1
]}

Zhang, Jian ^{[1
]}

机构：

[1] Hunan Univ, Coll Biol, Changsha 410082, Hunan, Peoples R China

[2] Zunyi Med Coll, Dept Biol Engn, Zhuhai Campus, Zhuhai 519041, Guangdong, Peoples R China

[3] Hunan Normal Univ, Coll Life Sci, Changsha 410000, Hunan, Peoples R China

[4] Hunan Normal Univ, Coll Med, Fac Basic Med Sci, Changsha 410013, Hunan, Peoples R China

来源：

JOURNAL OF CANCER | 2016年 / 7卷 / 05期

关键词：

lncRNA Z38; CLDND1; cell proliferation; tumorigenesis; oncogene; siRNA; GENE; CLAUDINS; GROWTH; MECHANISMS; CHROMATIN; RISK;

D O I：

10.7150/jca.13117

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aberrant expression of long noncoding RNAs (lncRNAs) has great impacts on cancer origination and progression. In the current study, a newly found lncRNA Z38, which was identified through combining experiments of suppression subtractive hybridization (SSH) and reverse dot-blotting, was found to have high expression in breast cancer. More importantly, inhibiting Z38 expression by gene silencing greatly suppressed breast cancer cell proliferation and tumorigenesis, and treatment with Z38 siRNAs significantly induced cell apoptosis and inhibited tumor growth. In conclusion, the newly found lncRNA Z38, which plays important roles in breast cancer, may act as a candidate biomarker and therapeutic target in carcinomas.

引用

页码：576 / 586

页数：11

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