Modeling neurodegenerative disorders in zebrafish

被引：44

作者：

Bashirzade, Alim A. ^{[1
,2
]}

Zabegalov, Konstantin N. ^{[3
]}

Volgin, Andrey D. ^{[1
,2
]}

Belova, Alisa S. ^{[1
,2
]}

Demin, Konstantin A. ^{[4
,5
,6
]}

de Abreu, Murilo S. ^{[7
]}

Babchenko, Vladislav Ya. ^{[1
,2
]}

Bashirzade, Kseniya A. ^{[1
]}

Yenkoyan, Konstantin B. ^{[10
,11
]}

Tikhonova, Maria A. ^{[1
,2
]}

Amstislavskaya, Tamara G. ^{[1
,2
]}

V. Kalueff, Allan ^{[8
,9
,11
,12
]}

机构：

[1] Novosibirsk State Univ, Inst Med & Psychol, Novosibirsk, Russia

[2] Sci Res Inst Neurosci & Med, Novosibirsk, Russia

[3] Sirius Univ Sci & Technol, Neurobiol Program, Soci, Russia

[4] St Petersburg State Univ, Inst Translat Biomed, St Petersburg, Russia

[5] Granov Sci Res Ctr Radiol & Surg Technol, St Petersburg, Russia

[6] Almazov Med Res Ctr, St Petersburg, Russia

[7] Moscow Inst Phys & Technol, Moscow, Russia

[8] Russian Acad Sci, Moscow, Russia

[9] Ural Fed Univ, Ekaterinburg, Russia

[10] M Heratsi Yerevan State Med Univ, COBRAIN Ctr, Neurosci Lab, Yerevan, Armenia

[11] COBRAIN Ctr, Sci Educ Ctr Fundamental Brain Res, Yerevan, Armenia

[12] Novosibirsk State Univ, Novosibirsk, Russia

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2022年 / 138卷

基金：

俄罗斯科学基金会;

关键词：

Neurodegenerative disorders; Dementia; Rodents; Zebrafish; Cognitive deficits; AMYOTROPHIC-LATERAL-SCLEROSIS; TRAUMATIC BRAIN-INJURY; TRANSCRANIAL MAGNETIC STIMULATION; AMYLOID PRECURSOR PROTEIN; NEURONAL CELL-DEATH; ALZHEIMERS-DISEASE; PONTOCEREBELLAR HYPOPLASIA; PARKINSONS-DISEASE; MULTIPLE-SCLEROSIS; ADULT ZEBRAFISH;

D O I：

10.1016/j.neubiorev.2022.104679

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Neurodegeneration is a major cause of Alzheimer's, Parkinson's, Huntington's, multiple and amyotrophic lateral sclerosis, pontocerebellar hypoplasia, dementia and other related brain disorders. Their complex pathogenesis commonly includes genetic and neurochemical deficits, misfolded protein toxicity, demyelination, apoptosis and mitochondrial dysfunctions. Albeit differing in specific underlying mechanisms, neurodegenerative disorders typically display evolutionarily conserved mechanisms across taxa. Here, we review the role of zebrafish models in recapitulating major human and rodent neurodegenerative conditions, demonstrating this species as a highly relevant experimental model for research on neurodegenerative diseases, and discussing how these fish models can further clarify the underlying genetic, neurochemical, neuroanatomical and behavioral pathogenic mechanisms.

引用

页数：13

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