Free radical scavenging, antioxidant enzymes and wound healing activities of leaves extracts from Clerodendrum infortunatum L.

被引：67

作者：

Gouthamchandra, K. ^{[1
]}

Mahmood, R. ^{[1
]}

Manjunatha, H. ^{[1
]}

机构：

[1] Kuvempu Univ, Dept PG Studies & Res Biotechnol & Bioinformat, Shimoga 577451, Karnataka, India

来源：

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY | 2010年 / 30卷 / 01期

关键词：

Clerodendrum infortunatum L; Antioxidant; Wound healing; CCl4; hepatotoxicity; RAT-LIVER; DEOXYRIBOSE; GLUTATHIONE; SUPEROXIDE; FLAVONOIDS;

D O I：

10.1016/j.etap.2010.03.005

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Three successive extracts of Clerodendrum infortunatum L leaves have been studied for their potential as antioxidants in 1,1-diphenyl-2-picrylhydrazyl (DPPH) model. The scavenging activity of ethanol extract was found to be high when compared to petroleum ether and chloroform extracts. Hence, it was selected to evaluate the beneficial properties using in vitro and in vivo models. The antioxidant and its protective effects against CCl4 induced oxidative stress in rats were significantly high. Further, to validate the traditional therapeutic claim, wound healing activity of the plant extracts was also carried out. Among the three extracts tested the petroleum ether and ethanol extracts exhibited a significant response. The presence of high antioxidant and pharmacological properties correlates to the total phenolic contents in the plant Clerodendrum infortunatum L. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：11 / 18

页数：8

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