Continuous production of (S)-1-phenylethanol by immobilized cells of Rhodotorula glutinis with a specially designed process

被引：18

作者：

Kurbanoglu, Esabi B. ^{[1
]}

Zilbeyaz, Kani ^{[2
]}

Kurbanoglu, Namudar I. ^{[3
]}

Ozdal, Murat ^{[1
]}

Taskin, Mesut ^{[1
]}

Algur, Omer F. ^{[1
]}

机构：

[1] Ataturk Univ, Dept Biol, Fac Sci, TR-25240 Erzurum, Turkey

[2] Agri Ibrahim Cecen Univ, Dept Chem, Fac Sci, TR-4100 Agri, Turkey

[3] Sakarya Univ, Dept Chem, Fac Hendek Educ, TR-54300 Sakarya, Turkey

来源：

TETRAHEDRON-ASYMMETRY | 2010年 / 21卷 / 04期

关键词：

RAM HORN PEPTONE; ASYMMETRIC REDUCTION; ENANTIOSELECTIVE REDUCTION; SUBSTITUTED ACETOPHENONES; BIOREDUCTION; YEAST;

D O I：

10.1016/j.tetasy.2010.01.019

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A specially designed process for the continuous production of a chiral alcohol by immobilized Rhodotorula glutinis was prepared and is reported. The performance of the process with immobilized cells was also investigated. The run time of the immobilized cells, the flow rates of the substrate, and tris buffer containing 4% glucose in the process were optimized. The immobilized R. glutinis biocatalyst could be used for 15 days with maximum reaction activity. Under the optimized conditions, the continuous production process was operated for 30 days and resulted in 10.8 mL (S)-1-phenylethanol [(S)-1-PE]. The process has been demonstrated on a multigram scale in 75% overall yield with a purity of >99%. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：461 / 464

页数：4

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