Light-sheet imaging for systems neuroscience

被引:47
作者
Keller, Philipp J. [1 ]
Ahrens, Misha B. [1 ]
Freeman, Jeremy [1 ]
机构
[1] Howard Hughes Med Inst, Ashburn, VA USA
关键词
PLANE ILLUMINATION MICROSCOPY; BRAIN ACTIVITY; EMBRYOS; SCALE; DEEP;
D O I
10.1038/nmeth.3214
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Developments in electrical, and optical. recording technology are scaling up the size of neuronal populations that can be monitored simultaneously. Light-sheet imaging is rapidly gaining traction as a method for optically, interrogating activity in large networks and presents both opportunities and challenges for understanding circuit function.
引用
收藏
页码:27 / 29
页数:3
相关论文
共 17 条
  • [1] Ahrens MB, 2013, NAT METHODS, V10, P413, DOI [10.1038/NMETH.2434, 10.1038/nmeth.2434]
  • [2] [Anonymous], 1902, ANN PHYS, DOI DOI 10.1002/ANDP.19023150102
  • [3] From Cosmos to Connectomes: The Evolution of Data-Intensive Science
    Burns, Randal
    Vogelstein, Joshua T.
    Szalay, Alexander S.
    [J]. NEURON, 2014, 83 (06) : 1249 - 1252
  • [4] Dimensionality reduction for large-scale neural recordings
    Cunningham, John P.
    Yu, Byron M.
    [J]. NATURE NEUROSCIENCE, 2014, 17 (11) : 1500 - 1509
  • [5] Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
    Fox, Michael D.
    Raichle, Marcus E.
    [J]. NATURE REVIEWS NEUROSCIENCE, 2007, 8 (09) : 700 - 711
  • [6] Freeman J, 2014, NAT METHODS, V11, P941, DOI [10.1038/NMETH.3041, 10.1038/nmeth.3041]
  • [7] Thin laser light sheet microscope for microbial oceanography
    Fuchs, E
    Jaffe, JS
    Long, RA
    Azam, F
    [J]. OPTICS EXPRESS, 2002, 10 (02): : 145 - 154
  • [8] Functional organization of glomerular maps in the mouse accessory olfactory bulb
    Hammen, Gary F.
    Turaga, Diwakar
    Holy, Timothy E.
    Meeks, Julian P.
    [J]. NATURE NEUROSCIENCE, 2014, 17 (07) : 953 - 961
  • [9] Fast three-dimensional fluorescence imaging of activity in neural populations by objective-coupled planar illumination microscopy
    Holekamp, Terrence F.
    Turaga, Diwakar
    Holy, Timothy E.
    [J]. NEURON, 2008, 57 (05) : 661 - 672
  • [10] Optical sectioning deep inside live embryos by selective plane illumination microscopy
    Huisken, J
    Swoger, J
    Del Bene, F
    Wittbrodt, J
    Stelzer, EHK
    [J]. SCIENCE, 2004, 305 (5686) : 1007 - 1009