Pancreatic Cancer Risk and ABO Blood Group Alleles: Results from the Pancreatic Cancer Cohort Consortium

被引：177

作者：

Wolpin, Brian M. ^{[1
,2
]}

Kraft, Peter ^{[5
,6
]}

Gross, Myron ^{[13
]}

Helzlsouer, Kathy ^{[14
]}

Bueno-de-Mesquita, H. Bas ^{[15
,16
]}

Steplowski, Emily ^{[17
]}

Stolzenberg-Solomon, Rachael Z. ^{[18
]}

Arslan, Alan A. ^{[21
,22
,23
]}

Jacobs, Eric J. ^{[24
]}

LaCroix, Andrea ^{[25
]}

Petersen, Gloria ^{[26
]}

Zheng, Wei ^{[27
,28
]}

Albanes, Demetrius ^{[18
]}

Allen, Naomi E. ^{[29
]}

Amundadottir, Laufey ^{[18
,19
]}

Anderson, Garnet ^{[25
]}

Boutron-Ruault, Marie-Christine ^{[30
,31
]}

Buring, Julie E. ^{[3
,4
,8
]}

Canzian, Federico ^{[32
]}

Chanock, Stephen J. ^{[18
,19
]}

Clipp, Sandra ^{[33
]}

Gaziano, John Michael ^{[9
,10
,11
,12
]}

Giovannucci, Edward L. ^{[2
,5
,7
]}

Hallmans, Goeran ^{[34
]}

Hankinson, Susan E. ^{[2
,5
]}

Hoover, Robert N. ^{[18
]}

Hunter, David J. ^{[2
,5
]}

Hutchinson, Amy ^{[18
,35
]}

Jacobs, Kevin ^{[18
,35
,36
]}

Kooperberg, Charles ^{[25
]}

Lynch, Shannon M. ^{[20
]}

Mendelsohn, Julie B. ^{[18
]}

Michaud, Dominique S. ^{[5
,37
]}

Overvad, Kim ^{[38
,39
]}

Patel, Alpa V. ^{[24
]}

Rajkovic, Aleksandar ^{[40
]}

Sanchez, Maria-Jose ^{[41
,42
]}

Shu, Xiao-Ou ^{[27
,28
]}

Slimani, Nadia ^{[43
]}

Thomas, Gilles ^{[18
]}

Tobias, Geoffrey S. ^{[18
]}

Trichopoulos, Dimitrios ^{[5
,44
]}

Vineis, Paolo ^{[37
]}

Virtamo, Jarmo ^{[45
]}

Wactawski-Wende, Jean ^{[46
]}

Yu, Kai ^{[18
]}

Zeleniuch-Jacquotte, Anne ^{[22
,23
]}

Hartge, Patricia ^{[18
]}

Fuchs, Charles S. ^{[1
,2
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA

[3] Brigham & Womens Hosp, Dept Med, Div Prevent Med, Boston, MA 02115 USA

[4] Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA 02115 USA

[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[6] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA

[7] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dept Ambulatory Care & Prevent, Boston, MA USA

[9] Brigham & Womens Hosp, Dept Med, Phys Hlth Study, Div Aging, Boston, MA 02115 USA

[10] Brigham & Womens Hosp, Dept Med, Phys Hlth Study, Div Cardiovasc Med, Boston, MA 02115 USA

[11] Brigham & Womens Hosp, Dept Med, Phys Hlth Study, Div Prevent Med, Boston, MA 02115 USA

[12] Vet Affairs Boston Healthcare Syst, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA

[13] Univ Minnesota, Sch Med, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA

[14] Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA

[15] Natl Inst Publ Hlth & Environm RIVM, Bilthoven, Netherlands

[16] Univ Med Ctr Utrecht, Dept Gastroenterol & Hepatol, Utrecht, Netherlands

[17] Informat Management Serv Inc, Silver Spring, MD USA

[18] NCI, Div Canc Epidemiol & Genet, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[19] NCI, Lab Translat Genom, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[20] NCI, Div Canc Control & Populat Sci, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[21] NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA

[22] NYU, Sch Med, Dept Environm Med, New York, NY USA

[23] NYU, Inst Canc, New York, NY USA

[24] Amer Canc Soc, Dept Epidemiol, Atlanta, GA 30329 USA

[25] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98104 USA

[26] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[27] Vanderbilt Univ, Dept Med, Div Epidemiol, Vanderbilt Epidemiol Ctr, Nashville, TN USA

[28] Vanderbilt Univ, Vanderbilt Ingram Canc Ctr, Nashville, TN USA

[29] Univ Oxford, Canc Epidemiol Unit, Oxford, England

[30] INSERM, Villejuif, France

[31] Inst Gustave Roussy, Villejuif, France

[32] German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany

[33] George W Comstock Ctr Publ Hlth Res & Prevent, Hagerstown, MD USA

[34] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[35] NCI, Core Genotyping Facil, Adv Technol Program, Sci Applicat Int Corp Frederick Inc,, Frederick, MD 21701 USA

[36] Bioinformed Consulting Serv, Gaithersburg, MD USA

[37] Univ London Imperial Coll Sci Technol & Med, Div Epidemiol Publ Hlth & Primary Care, London, England

[38] Aarhus Univ Hosp, Aalborg Hosp, Dept Cardiol, Aalborg, Denmark

[39] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[40] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA

[41] Andalusian Sch Publ Hlth, Granada, Spain

[42] CIBER Epidemiol & Salud Publ, Granada, Spain

[43] IARC, Lyon, France

[44] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-11527 Athens, Greece

[45] Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland

[46] SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA

来源：

CANCER RESEARCH | 2010年 / 70卷 / 03期

关键词：

GROUP ANTIGENS; GENETIC-BASIS; STRATIFICATION; ASSOCIATION; VARIANTS;

D O I：

10.1158/0008-5472.CAN-09-2993

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk. Cancer Res; 70(3); 1015-23. (C)2010 AACR.

引用

页码：1015 / 1023

页数：9

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