Fatal donor-derived Kaposi sarcoma following liver transplantation

被引：7
作者：
Copeland, Matthew Moore McCrea [1 ]
Trainor, James [2 ]
Cash, W. Johnny [1 ]
Braniff, Conor [1 ]
机构：
[1] Belfast Hlth & Social Care Trust, Reg Liver Unit, Belfast, Antrim, North Ireland
[2] Belfast Hlth & Social Care Trust, Inst Pathol, Royal Victoria Hosp, Belfast, Antrim, North Ireland
来源：
BMJ CASE REPORTS | 2021年 / 14卷 / 06期
关键词：
malignant disease and immunosuppression; gastroenterology; liver disease; infectious diseases; transplantation; INFECTION; MORBIDITY; DISEASE;
D O I：
10.1136/bcr-2020-236061
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Human herpesvirus-8 (HHV8) is a recognised precursor for a number of neoplastic and non-neoplastic processes. Immunosuppressed recipients of both solid organ and haematopoietic stem cell transplants are at risk of life-threatening lytic reactivations of HHV8-infected B-lymphocytes, primary infections after receiving grafts from HHV8-seropositive donors and more rarely by the direct transplantation of malignant Kaposi sarcoma cells seeded within graft tissue. We describe the case of an HHV8-seronegative patient with confirmed, post-orthotopic liver transplant transmission of HHV8 from a seropositive donor with quantitative evidence of viraemia and subsequent development of disseminated visceral and cutaneous Kaposi sarcoma with a rapidly fatal outcome.
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页数：4
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