Biomarker discovery from uveal melanoma secretomes:: Identification of gp100 and cathepsin D in patient serum

被引：49
作者：
Pardo, Maria
Garcia, Angel
Antrobus, Robin
Blanco, Maria Jose
Dwek, Raymond A.
Zitzmann, Nicole
机构：
[1] Univ Oxford, Oxford Glycobiol Inst, Dept Biochem, Oxford O1 3QU, England
[2] Univ Santiago de Compostela, RIAIDT, Santiago De Compostela, Spain
[3] CACTUS, Santiago De Compostela 15782, Spain
[4] Univ Santiago de Compostela, Hosp Conxo, Serv Oftalmol, Santiago De Compostela 15706, Spain
来源：
JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 07期
关键词：
uveal melanoma; proteomics; secretome; biomarker; cathepsin D; syntenin; gp100; PROMOTES CELL-MIGRATION; TUMOR-DERIVED EXOSOMES; PROTEOMIC ANALYSIS; GASTRIC-CANCER; EXPRESSION; PROTEINS; AUTOANTIBODIES; BREAST; METASTASIS; L1;
D O I：
10.1021/pr070021t
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
There is a necessity to better characterize uveal melanoma (UM) tumors according to their metastasis potential at an early stage. In this study we report the identification of potential biomarkers by a combination of proteomics-related approaches: the characterization of UM cell secretomes, the analysis of UM autoantibodies, and the differential depleted serum proteome analysis. We describe a possible role of cathepsin D, syntenin, and gp100 in UM as potential biomarkers.
引用
收藏
页码：2802 / 2811
页数：10
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