Copper(II)-catalyzed C5 and C7 halogenation of quinolines using sodium halides under mild conditions

被引：117

作者：

Xu, Jun ^{[1
]}

Zhu, Xiaolei ^{[1
]}

Zhou, Guobin ^{[2
]}

Ying, Beibei ^{[1
]}

Ye, Pingping ^{[1
]}

Su, Lingying ^{[1
]}

Shen, Chao ^{[3
]}

Zhang, Pengfei ^{[1
]}

机构：

[1] Hangzhou Normal Univ, Coll Mat Chem & Chem Engn, Hangzhou 310036, Zhejiang, Peoples R China

[2] Zhejiang Yongtai Technol Co Ltd, Linhai 317016, Peoples R China

[3] Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Zhejiang, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 11期

基金：

中国国家自然科学基金;

关键词：

H BOND ACTIVATION; CATALYZED ORTHO-HALOGENATION; SELECTIVE ORTHO-BROMINATION; TRANSITION-METAL-COMPLEXES; ONE-POT SYNTHESIS; N-OXIDES; DIRECTING-GROUP; BIFUNCTIONAL ORGANOCATALYSTS; WEAK COORDINATION; COUPLING REACTION;

D O I：

10.1039/c6ob00169f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and mild protocol for copper catalyzed halogenation of quinoline at C5 and C7 positions was developed, affording the desired remote C-H activation products in moderate to good yields. This reaction proceeds with low-cost sodium halides (NaX, X = Cl, Br, I) and features excellent substrate tolerance. A series of control experiments were carried out to illustrate a single-electron-transfer process which plays a vital role in the halogenation.

引用

页码：3016 / 3021

页数：6

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