Blood's life history traced through genomic scars

被引:0
作者
Sekar, Aswin [1 ]
Ebert, Benjamin L. [1 ,2 ]
机构
[1] Dana Farber Canc Inst, Dept Med, Boston, MA 02215 USA
[2] Howard Hughes Med Inst, Boston, MA 02115 USA
关键词
Genetics; Stem cells; Ageing;
D O I
10.1038/d41586-022-01304-y
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Two studies of the mutations acquired by blood-forming cells over time provide insights into the dynamics of blood production in humans and its relationship to ageing.
引用
收藏
页码:255 / 256
页数:2
相关论文
共 9 条
  • [1] Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells
    Bao, Erik L.
    Nandakumar, Satish K.
    Liao, Xiaotian
    Bick, Alexander G.
    Karjalainen, Juha
    Tabaka, Marcin
    Gan, Olga, I
    Havulinna, Aki S.
    Kiiskinen, Tuomo T. J.
    Lareau, Caleb A.
    Portilla, Aitzkoa L. de Lapuente
    Li, Bo
    Emdin, Connor
    Codd, Veryan
    Nelson, Christopher P.
    Walker, Christopher J.
    Churchhouse, Claire
    de la Chapelle, Albert
    Klein, Daryl E.
    Nilsson, Bjorn
    Wilson, Peter W. F.
    Cho, Kelly
    Pyarajan, Saiju
    Gaziano, J. Michael
    Samani, Nilesh J.
    Regev, Aviv
    Palotie, Aarno
    Neale, Benjamin M.
    Dick, John E.
    Natarajan, Pradeep
    O'Donnell, Christopher J.
    Daly, Mark J.
    Milyavsky, Michael
    Kathiresan, Sekar
    Sankaran, Vijay G.
    [J]. NATURE, 2020, 586 (7831) : 769 - 775
  • [2] Inherited causes of clonal haematopoiesis in 97,691 whole genomes
    Bick, Alexander G.
    Weinstock, Joshua S.
    Nandakumar, Satish K.
    Fulco, Charles P.
    Bao, Erik L.
    Zekavat, Seyedeh M.
    Szeto, Mindy D.
    Liao, Xiaotian
    Leventhal, Matthew J.
    Nasser, Joseph
    Chang, Kyle
    Laurie, Cecelia
    Burugula, Bala Bharathi
    Gibson, Christopher J.
    Lin, Amy E.
    Taub, Margaret A.
    Aguet, Francois
    Ardlie, Kristin
    Mitchell, Braxton D.
    Barnes, Kathleen C.
    Moscati, Arden
    Fornage, Myriam
    Redline, Susan
    Psaty, Bruce M.
    Silverman, Edwin K.
    Weiss, Scott T.
    Palmer, Nicholette D.
    Vasan, Ramachandran S.
    Burchard, Esteban G.
    Kardia, Sharon L. R.
    He, Jiang
    Kaplan, Robert C.
    Smith, Nicholas L.
    Arnett, Donna K.
    Schwartz, David A.
    Correa, Adolfo
    de Andrade, Mariza
    Guo, Xiuqing
    Konkle, Barbara A.
    Custer, Brian
    Peralta, Juan M.
    Gui, Hongsheng
    Meyers, Deborah A.
    McGarvey, Stephen T.
    Chen, Ida Yii-Der
    Shoemaker, M. Benjamin
    Peyser, Patricia A.
    Broome, Jai G.
    Gogarten, Stephanie M.
    Wang, Fei Fei
    [J]. NATURE, 2020, 586 (7831) : 763 - +
  • [3] Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations
    Chen, Ming-Huei
    Raffield, Laura M.
    Mousas, Abdou
    Sakaue, Saori
    Huffman, Jennifer E.
    Moscati, Arden
    Trivedi, Bhavi
    Jiang, Tao
    Akbari, Parsa
    Vuckovic, Dragana
    Bao, Erik L.
    Zhong, Xue
    Manansala, Regina
    Laplante, Veronique
    Chen, Minhui
    Lo, Ken Sin
    Qian, Huijun
    Lareau, Caleb A.
    Beaudoin, Melissa
    Hunt, Karen A.
    Akiyama, Masato
    Bartz, Traci M.
    Ben-Shlomo, Yoav
    Beswick, Andrew
    Bork-Jensen, Jette
    Bottinger, Erwin P.
    Brody, Jennifer A.
    van Rooij, Frank J. A.
    Chitrala, Kumaraswamynaidu
    Cho, Kelly
    Choquet, Helene
    Correa, Adolfo
    Danesh, John
    Di Angelantonio, Emanuele
    Dimou, Niki
    Ding, Jingzhong
    Elliott, Paul
    Esko, Tonu
    Evans, Michele K.
    Floyd, James S.
    Broer, Linda
    Grarup, Niels
    Guo, Michael H.
    Greinacher, Andreas
    Haessler, Jeff
    Hansen, Torben
    Howson, Joanna M. M.
    Huang, Qin Qin
    Huang, Wei
    Jorgenson, Eric
    [J]. CELL, 2020, 182 (05) : 1198 - +
  • [4] The longitudinal dynamics and natural history of clonal haematopoiesis
    Fabre, Margarete A.
    de Almeida, Jose Guilherme
    Fiorillo, Edoardo
    Mitchell, Emily
    Damaskou, Aristi
    Rak, Justyna
    Orru, Valeria
    Marongiu, Michele
    Chapman, Michael Spencer
    Vijayabaskar, M. S.
    Baxter, Joanna
    Hardy, Claire
    Abascal, Federico
    Williams, Nicholas
    Nangalia, Jyoti
    Martincorena, Inigo
    Campbell, Peter J.
    McKinney, Eoin F.
    Cucca, Francesco
    Gerstung, Moritz
    Vassiliou, George S.
    [J]. NATURE, 2022, 606 (7913) : 335 - +
  • [5] Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes
    Jaiswal, Siddhartha
    Fontanillas, Pierre
    Flannick, Jason
    Manning, Alisa
    Grauman, Peter V.
    Mar, Brenton G.
    Lindsley, R. Coleman
    Mermel, Craig H.
    Burtt, Noel
    Chavez, Alejandro
    Higgins, John M.
    Moltchanov, Vladislav
    Kuo, Frank C.
    Kluk, Michael J.
    Henderson, Brian
    Kinnunen, Leena
    Koistinen, Heikki A.
    Ladenvall, Claes
    Getz, Gad
    Correa, Adolfo
    Banahan, Benjamin F.
    Gabriel, Stacey
    Kathiresan, Sekar
    Stringham, Heather M.
    McCarthy, Mark I.
    Boehnke, Michael
    Tuomilehto, Jaakko
    Haiman, Christopher
    Groop, Leif
    Atzmon, Gil
    Wilson, James G.
    Neuberg, Donna
    Altshuler, David
    Ebert, Benjamin L.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (26) : 2488 - 2498
  • [6] Clonal dynamics of haematopoiesis across the human lifespan
    Mitchell, Emily
    Spencer Chapman, Michael
    Williams, Nicholas
    Dawson, Kevin J.
    Mende, Nicole
    Calderbank, Emily F.
    Jung, Hyunchul
    Mitchell, Thomas
    Coorens, Tim H. H.
    Spencer, David H.
    Machado, Heather
    Lee-Six, Henry
    Davies, Megan
    Hayler, Daniel
    Fabre, Margarete A.
    Mahbubani, Krishnaa
    Abascal, Federico
    Cagan, Alex
    Vassiliou, George S.
    Baxter, Joanna
    Martincorena, Inigo
    Stratton, Michael R.
    Kent, David G.
    Chatterjee, Krishna
    Parsy, Kourosh Saeb
    Green, Anthony R.
    Nangalia, Jyoti
    Laurenti, Elisa
    Campbell, Peter J.
    [J]. NATURE, 2022, 606 (7913) : 343 - +
  • [7] Somatic mutations and cell identity linked by Genotyping of Transcriptomes
    Nam, Anna S.
    Kim, Kyu-Tae
    Chaligne, Ronan
    Izzo, Franco
    Ang, Chelston
    Taylor, Justin
    Myers, Robert M.
    Abu-Zeinah, Ghaith
    Brand, Ryan
    Omans, Nathaniel D.
    Alonso, Alicia
    Sheridan, Caroline
    Mariani, Marisa
    Dai, Xiaoguang
    Harrington, Eoghan
    Pastore, Alessandro
    Cubillos-Ruiz, Juan R.
    Tam, Wayne
    Hoffman, Ronald
    Rabadan, Raul
    Scandura, Joseph M.
    Abdel-Wahab, Omar
    Smibert, Peter
    Landau, Dan A.
    [J]. NATURE, 2019, 571 (7765) : 355 - +
  • [8] The Polygenic and Monogenic Basis of Blood Traits and Diseases
    Vuckovic, Dragana
    Bao, Erik L.
    Akbari, Parsa
    Lareau, Caleb A.
    Mousas, Abdou
    Jiang, Tao
    Chen, Ming-Huei
    Raffield, Laura M.
    Tardaguila, Manuel
    Huffman, Jennifer E.
    Ritchie, Scott C.
    Megy, Karyn
    Ponstingl, Hannes
    Penkett, Christopher J.
    Albers, Patrick K.
    Wigdor, Emilie M.
    Sakaue, Saori
    Moscati, Arden
    Manansala, Regina
    Lo, Ken Sin
    Qian, Huijun
    Akiyama, Masato
    Bartz, Traci M.
    Ben-Shlomo, Yoav
    Beswick, Andrew
    Bork-Jensen, Jette
    Bottinger, Erwin P.
    Brody, Jennifer A.
    van Rooij, Frank J. A.
    Chitrala, Kumaraswamy N.
    Wilson, Peter W. F.
    Choquet, Helene
    Danesh, John
    Di Angelantonio, Emanuele
    Dimou, Niki
    Ding, Jingzhong
    Elliott, Paul
    Esko, Tonu
    Evans, Michele K.
    Felix, Stephan B.
    Floyd, James S.
    Broer, Linda
    Grarup, Niels
    Guo, Michael H.
    Guo, Qi
    Greinacher, Andreas
    Haessler, Jeff
    Hansen, Torben
    Howson, Joanna M. M.
    Huang, Wei
    [J]. CELL, 2020, 182 (05) : 1214 - +
  • [9] Weinstock J. S., BIORXIV, DOI [10.1101/2021.12.10.471810(2021, DOI 10.1101/2021.12.10.471810(2021]